Background: Heavy menstrual bleeding (HMB) is defined as cyclical bleeding at regular intervals but excessive in amount which affect the physical, social and mental aspects of life of a woman. The prevalence is 10-30% in reproductive age women and 50% in perimenopausal women. HMB is not just a clinical burden but also a huge social and economic burden. The aims and objective of my study is to compare the efficacy of diosmin and tranexamic acid in acute HMB in terms of average duration of menstrual cycle, PBAC/PABC score, endometrial thickness, hemoglobin concentration and finally need for other modes of treatment.Methods: The study was a randomized control trial in which the patients (sample size-72) were divided into two groups- group D (n=36) and group T (n=36). Group D was treated with tab diosmin 500 mg thrice daily from day 1 to day 5 of menstrual cycle. Similarly group T was treated with tab tranexamic acid 500 mg thrice daily from day 1 to day 5 of menstrual cycle. The PBAC score was taken at the end of three months along with endometrial thickness and hemoglobin concentration. The results were compared with values obtained before initiating treatment.Results: In this study after 3 months of treatment; the patients in group D had an initial PBAC score of 423.52 and at the end of treatment it was decreased to 149.89 (p<0.0001). Reduction was 60.5%. Group T patients had an initial PBAC score of 441which was reduced to 177.94 (p<0.0001) after treatment. The reduction in this group was 59.6%.Conclusions: In this study it was found that both tranexamic acid and diosmin were effective in reduction of HMB, in terms of PBAC score, average duration of menstrual cycle and endometrial thickness. But the in reduction in PBAC score was similar in both the groups. The failure rates were also similar in both the groups, but improvements in hemoglobin concentration were only marginal

Introduction: Hypertensive disorders complicates 5-10% of pregnancies all over the world and its incidence in India was found to be 10.08% as per data of National Eclampsia Registry (NEP). Objectives: The objectives of this study were to determine the incidence of abnormal liver, renal and cerebral function test among patients with preeclampsia and eclampsia and their correlation to maternal and fetal outcome. Methodology: The study was a prospective cohort study comparing the maternal and fetal outcomes of preeclampsia and eclampsia patients with abnormal parameters (cases; n=50) and pre-eclampsia and eclampsia patients with normal parameters (controls; n=50).  Both case and control were examined clinically apart from biophysical and biochemical investigation. Results:  Deranged LFT was present in approximately 56% -70% of cases. Serum albumin was decreased in 80% of cases. Prothrombin time (PT) was raised in 48% of cases. Abnormal GFR, urea, creatinine and uric acid level were present in 44%, 10%, 10% and 64% of cases. Among all the pregnancy outcomes in preeclampsia and eclampsia cases with abnormal LFT, preterm labour, PPH, IUFD, meconium stained liquor and neonatal death had significant “p” value <.05. There were 16% preterm labours, 60% IUGR, 36% ARF, 18% Neonatal death, in cases with abnormal RFT. It was found from the study that CVA, Cerebral hemorrhage, fetal distress, and still birth were present in 16%, 24%, 36% and 8% of cases with abnormal cerebral function. Conclusion: Deranged liver function test was associated with increased incidence of postpartum hemorrhage (P value=0.0001) and postpartum eclampsia (P value <0.0001).