Commercially available Quadrol, N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine (THPEN), has been used for the first time as N^N- donor neutral hydrophilic ligand in the synthesis and characterization of new water soluble palladium (II) complexes...

Nucleosides modification via conventional cross-coupling has been performed using different catalytic systems and found to take place via long reaction times. However, since the pandemic, nucleoside-based antivirals and vaccines have received widespread attention and the requirement for rapid modification and synthesis of these moieties has become a major objective for researchers. To address this challenge, we describe the development of a rapid flow-based cross-coupling synthesis protocol for a variety of C5-pyrimidine substituted nucleosides. The protocol allows for facile access to multiple nucleoside analogues in very good yields in a few minutes compared to conventional batch chemistry. To highlight the utility of our approach, the synthesis of an anti-HSV drug, BVDU was also achieved in an efficient manner using our new protocol.

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We have utilized N-benzoyl cytosine for efficient transamidation and esterification via catalytic C–N bond cleavage. The one-pot strategy involves the reaction of secondary amide with various aliphatic or aromatic amines...

A novel and efficient approach has been developed for the direct synthesis of pyrimidinyl dimethylcarbamate using Cu-PMo 12 complex. Basically, Cu-PMA catalyst successfully enabled the cross-dehydrogenative coupling (CDC) reaction between N-benzoyl cytosine and formamides in the presence of tert-butyl hydroperoxide and triethyl amine. Herein, Cu(I/II) catalytic system facilitated the oxidative coupling of the carbamide function, generating a new CÀ O bond and has been identified as more efficient compared to other commercially available Cu (I) or Cu (II) salts. Furthermore, the characterization of the catalyst was performed by XPS, SEM and EDX analysis. The present method also demonstrates a simple procedure with least catalyst loading, a wide variety of substrates with excellent functional group compatibility, high yields, ambient conditions, and operational simplicity.