Tyrosine kinase inhibitors (TKIs) are used as targeted therapy for cancer by inhibiting the signaling pathway and tumor growth. Many TKIs got approved by FDA in recent times for the treatment of cancer by oral route. However, the TKIs have formulation challenges leading to compromised bioavailability which can cause a weak therapeutic response. The cancer nanotherapeutics using nanocarriers based drug delivery has emerged as an advanced tool to provide a solution to formulation challenges and a better cancer therapy by overcoming the limitations in conventional cancer therapy. This review describes the various formulation issues of anticancer drugs with a special reference to TKIs, as well as the capability of solid lipid nanoparticles for an efficient nano targeted cancer drug delivery.

Background: The advanced development of lipid nanocarrier contributes a lot to the domain of therapeutic effectiveness of the drug. However the parameter such as drug loading, drug release, stability, and targeting influence much more towards the limitation of many lipid nanocarriers. The Nanostructured lipid carrier, the second generation of lipid carrier has more promising advantages over others and have tremendous targeting ability to skin for drug administration. Objective: The present review paper focus to understand the different fabrication technique, impact of lipid and surfactant on formulation effectiveness, characterization of formulation, and Crystalinity concept of lipid which have an impact on stability & drug loading. Focus on a parameter such as Transepidermal water loss , skin occlusion, and hydration which determine the ability of the carrier to target the skin. Hence the effectiveness of the drug improved. This review also focused on patents based on Nanostructured lipid carriers. Method of preparation: many methods have been adopted to prepare Nanostructured lipid carriers and among all High-pressure homogenization method is considered as best one. Conclusion: Because of numerous advantages of this carrier system such as biocompatibility of lipid, high drug encapsulation, stability over others, it is considered as a major focused area for researchers. The new domain of Nanostructured lipid carrier is transdermal drug administration by targeting the skin; hence more research is focused on topical preparation. However, toxicity must have to be studied in humans. So by considering all factors one can rename it as “smart nano lipid carrier".