Objective: This study aimed to evaluate the ability of intravenous glucose administration during the maintenance of anesthesia as an alternative method for diminishing the incidence of postoperative nausea and vomiting (PONV) in patients undergoing total abdominal hysterectomy (TAH).Material and Methods: This was a prospective, double-blind randomized placebo-controlled trial. One hundred and ten patients who were 18 - 65 years old, American Society of Anesthesiology (ASA) 1 or 2 and required general anesthesia for TAH, were divided randomly to receive 5% DNSS (Group D) or normal saline (Group N) as a maintenance fluid at a rate of 2 mL/kg/hr. The primary outcome was the incidence of PONV at the arrival time in post-anesthetic care unit (PACU). The secondary outcomes were severity of PONV, time to first dose of an antiemetic drug, amount of antiemetic dose, and length of stay in the hospital.Results: The incidence of PONV in group N was 5.5% and in group D was 10.4% (p-value = 0.360). There were no statistically significant differences regarding the VRS scores, time to the first dose of antiemetic drug, the amount of antiemetic drug, and length of hospital stay between the 2 groups.Conclusions: There was no significant difference in efficacy between intravenous glucose administration and placebo in the prevention of PONV in patients undergoing abdominal hysterectomy under general anesthesia.

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