This research used quasi experimental method with treatment design by level 2x2. The research instrument used multiple-choice tests to measure learning outcomes and quotionare to measure student self-efficacy. Data analysis techniques include test requirements analysis and hypothesis testing. The collected data was analyzed by using two path Anava test. The result of the research (1) Ho which read the outcome of studying the subject of Psychiatric Nursing on the students which is learned by PBL learning strategy is rejected. (2) Ho that there is no influence of interaction between PBL learning strategy and self efficacy to outcome of Psychiatric Nursing is rejected. (3) Ho that sounds the outcome of studying the subject of Psychiatric Nursing to students who are taught by PBL learning strategy for students who have high self efficacy rejected. (4) Ho that reads the outcome of study of Psychiatric Nursing subjects on the students with low self efficacy which is taught by PBL learning strategy rejected.