In this paper, an investigation of the role of nuclear saturation parameters on f-mode oscillations in neutron stars is performed within the Cowling approximation. It is found that the uncertainty in the effective nucleon mass plays a dominant role in controlling the f-mode frequencies. The effect of the uncertainties in saturation parameters on previously-proposed empirical relations of the frequencies with astrophysical observables relevant for asteroseismology are also investigated. These results can serve as an important tool for constraining the nuclear parameter space and understand the behaviour of dense nuclear matter from the future detection of f-modes.