BACKGROUNDWith improved neonatal care and better survival rate of premature babies, incidence of Retinopathy of Prematurity (ROP) in our country is on the increasing trend. As we know there are many foetal and maternal risk factors influencing the development of ROP, not all preterm babies develop ROP. MATERIALS AND METHODSThe aim of this study is to determine the effect of maternal pre-eclampsia on development and severity of ROP among preterm babies delivered in our Govt. Rajaji Hospital; 200 babies with birth weight less than 1750 grams and less than 34 weeks of gestation were taken up for this prospective observational study. Babies of mothers with gestational hypertension, eclampsia, chronic hypertension, preeclampsia superimposed on chronic hypertension, babies with congenital anomalies and who expired before completion of ROP screening were excluded. RESULTSAmong 140 babies of normotensive mothers and 60 babies of preeclampsia mothers, 43.6% and 45% had developed any stage of ROP respectively. Incidence of severe ROP in babies of normotensive mothers was 13.6%, whereas it was 3.3% in babies of preeclampsia mothers. Statistical analysis done using student's t-test, "P" value was found to be < 0.05. CONCLUSIONWe conclude that maternal preeclampsia is a protective factor for the development of severe ROP. KEYWORDS BACKGROUNDRetinopathy of Prematurity (ROP) is a disease characterised by abnormalities in the vascular development of retina in premature infants. With improved neonatal care and better survival rate of premature babies, incidence of ROP in our country is on the increasing trend. ROP incidence increases 1 with decreasing Gestational Age (GA) and Birth Weight (BW); however, not in all preterm babies. So, there might be other foetal and/or maternal risk factors influencing the development of ROP. These factors may protect or increase the probability of development of ROP.

BACKGROUND Maintenance of Intraocular Pressure and its pathophysiology revolves around the aqueous dynamics, and this is almost always the cause of Primary Open Angle Glaucoma and thus becoming the target for many medical and surgical therapies. Deep sclerectomy still holds an equal place in management. As in deep sclerectomy there is non-invasion of the anterior chamber, the reduced postoperative complications like over filtration and hypotony are rare. Aims and Objectives-To evaluate and compare the results of trabeculectomy and deep sclerectomy in mild and moderate primary open angle glaucoma patients and assess their intraocular pressure pre-operatively and post-operatively. MATERIALS AND METHODSThis was a prospective randomised trial conducted among 50 patients with mild or moderate primary open angle glaucoma at Government Rajaji Hospital for a period of nine months. All subjects were evaluated pre-operatively and randomly divided into 2 groups using simple randomisation method. IOP was measured on the 3 rd post-operative day followed by weekly intervals for 1 month and monthly intervals thereafter till 6 months. RESULTSMale-to-female ratio was almost equal in both groups. There was significant reduction of IOP post-operatively in the trabeculectomy as well as the deep sclerectomy groups, right from the 3 rd post-operative day till the 6 th month. The advantages of deep sclerectomy over trabeculectomy in open angle glaucoma are safety without loss of efficacy with fewer complications and faster recovery. However, the long-term efficacy of IOP control in deep sclerectomy is poor, unlike in trabeculectomy, in which case a number of adjunctive techniques are being used to increase the efficacy like intraoperative use of antimetabolites, Ologen like intrascleral implants as well as performing laser goniopuncture early when the IOP rises above the target value. CONCLUSIONDeep sclerectomy were equally effective in reducing the intraocular pressure in POAG patients during the immediate postoperative and up to 6 months of follow-up period. Deep sclerectomy henceforth should be considered at an earlier stage. KEYWORDSIntraocular Pressure, Open Angle Glaucoma, Trabeculectomy, Anti-Glaucoma Surgery. HOW TO CITE THIS ARTICLE: Parvathasundari N, Chandrakumar S, Sowmi SK, et al. A prospective non-randomised trial to compare the results of intraocular pressure reduction between trabeculectomy and deep sclerectomy in primary open angle glaucoma.