Plastic materials are ubiquitous in our environment due to increased demand and poor management. Therein, these materials find their way into biological systems on land and water, leading to public health problems. Plastics become fragmented or degraded to yield smaller particles that enter into the body, which may be retained or translocated to organs and tissues. Thus, this paper identifies common fates and biochemical interaction with biological system and creates awareness and measures to curtail the escalating trend of plastics dangers in our environment.