Hesperidin is a bioflavonoid constituent that among many other biological activities shows significant wound healing properties. However, the bioavailability of hesperidin when applied topically is limited due to its low solubility and systemic absorption, so novel dosage forms are needed to improve its therapeutic efficacy. The objectives of this study were to develop hesperidin-loaded lipid-polymer hybrid nanoparticles (HLPHNs) to enhance the delivery of hesperidin to endogenous sites in the wound bed and promote the efficacy of hesperidin. HLPHNs were optimized by response surface methodology (RSM) using the Box-Behnken design. HLPHNs were prepared using an emulsion-solvent evaporation method based on a double emulsion of water-in-oil-in-water (w/o/w) followed by freeze-drying to obtain nanoparticles. The prepared formulations were characterized using various evaluation parameters. In addition, the antioxidant activity of HLPHN 4 was investigated in vitro using the DPPH model. Seventeen different HLPHNs were prepared and the HLPHN4 exhibited the best mean particle size distribution, zeta potential, drug release and entrapment efficiency. The values are 91.43 nm, +23 mV, 79.97% and 92.8%, respectively. Transmission electron microscope showed similar spherical morphology as HLPHN4. Differential scanning calorimetry verified the physical stability of the loaded drug in a hybrid system. In vitro release studies showed uniform release of the drug over 24 h. HLPHN4 showed potent antioxidant activity in vitro in the DPPH model. The results of this study suggest that HLPHNs can achieve sustained release of the drug at the wound site and exhibit potent in vitro antioxidant activity.

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According to WHO, he SARS-CoV-2 Coronavirus malady to begin with showed up in Wuhan, China in December 2019 and rapidly spread to more than 200 nations, coming about in a worldwide wellbeing widespread. There are over 3.5 million affirmed cases and between 165,000 and 243,000 fatalities. The essential signs are respiratory and cardiac, but neurological highlights have too been detailed in case reports and case arrangement with in the writing. Headache and tipsiness are the ore most detailed side effects, taken after by encephalopathy and daze cerebrovascular mischance, Guillian barre disorder, intense transverse myelitis, and intense encephalitis are among the complications famous. Hyposmia was the foremost common fringe appearance. It ought to moreover be famous that neurological appearances can in some cases go before normal highlights such as fever and hack, and those normal signs create afterward in these patients. Our objective is to advise neurologists and doctors who are treating suspected COVID19cases around the conceivable neurological introductions, plausible neurological complications, and the different treatment options available, to consider the long run of this worldwide widespread, and to distinguish a few potential alternatives that may revolutionize the treatment of this novel infection disease. We provide an outline of the current information concerning neurological appearances related with COVID-19, to the extent that literature is already available as the pandemic is still progressing.

Hyperglycemia is a metabolic illness characterized by diabetes mellitus. Chronic hyperglycemia can lead to infection, production of more reactive oxygen species, chronic inflammation, and impaired angiogenesis, thus increasing the wound’s healing time. As the diabetic wound healing process is a more complex pathology, the demand to develop a topical application has emerged. This review focuses on the diabetic wound, wound healing, and the factors that influence diabetic wound healing. It also highlights the impact of combination delivery of antibiotics and antioxidants loaded with multifunctional hydrogel on diabetic wound healing. Due to the immense financial strain caused by this pathology, there is a need for other effective novel methods for wound healing. Therefore, multifunctional hydrogels, which are effective and have been used mainly as a carrier system for diabetic wound treatment, have been studied. Hence, the application of antibiotics and antioxidants loaded with multifunctional hydrogel in treating diabetic wounds is reviewed. Hydrogels present a significant theoretical reference for diabetic wound healing.