The human skin is the largest sensory organ, made up of complex sensors that detect noxious stimuli to rapidly send warning signals to the central nervous system to initiate a motor response. It is complex to mimic key skin features using existing tactile sensors, and there exists no somatosensor that responds to real stimuli of pressure, temperature, and touch. Herein, three critical skin receptors created by realizing integrated electronic systems that mimic the feedback response of somatosensors are experimentally demonstrated. Fully functional Pacinian corpuscles, thermoreceptors, and nociceptors are realized using a combination of stretchable pressure sensors, phase‐change oxide thin films, and threshold‐based resistive switching (memristor) memory elements. The ability to detect and respond to pressure, temperature, and pain stimuli above a threshold with real‐life performance characteristics is demonstrated with explanation of underlying mechanisms. The ability to design and realize artificial skin receptors enables replacement of affected human skin regions, augment skin sensitivity for agile applications in defense and sports, and drive advancements in intelligent robotics.

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