No abstract

No abstract

Powerful packages based on multibody dynamics can solve virtually any dynamic system. But to the user they are black boxes. Kinematic analysis of plane mechanisms is vital to mechanical engineering. This analysis hardly requires such versatile tools. Further blind usage of these powerful tools does not permit the user to develop insight into the mechanisms. On the other hand, packages based on simple but modular approach are ideally suited for the purpose. The aim of the preset work is to rigorously define the independently solvable modules and to develop a program using these modules, on MATLAB platform, which can solve a large variety of plane mechanisms.

A key initiating step in atherosclerosis is the accumulation and retention of apolipoprotein B complexing lipoproteins within artery walls. In this work, we address this exact initiating mechanism of atherosclerosis, which results from the oxidation of low-density lipoproteins (oxLDL) using therapeutic nanogels. We present the development of biocompatible polyethylene glycol (PEG) crosslinked nanogels formed from a single simultaneous cross-linking and copolymerization step in water without the requirement for organic solvent, high temperature or shear stress. The nanogel synthesis also incorporates in situ non-covalent electrostatically driven template polymerization around an innate anti-inflammatory and anti-oxidizing paraoxonase-1 (PON-1) enzyme payload -the release of which is triggered due to matrix metalloproteinase (MMP) responsive elements instilled in the PEG crosslinker monomer. Results obtained demonstrate the potential of triggered release of PON-1 enzyme and its efficacy against the production of ox-LDL and therefore a reduction in macrophage foam cell and reactive oxygen species formation.

therosclerosis is a leading cause of death worldwide. Antioxidant therapy has been considered a promising treatment modality for atherosclerosis, since reactive oxygen species (ROS) play a major role in the...