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The purpose of this study was to analyse selfefficacy for cancer patients and volunteers who consumed nanogold and nanosilver medication. The self-efficacy I consider here includes intention to obtain information, persistence, and results of performance. In this paper, self-efficacy means a person's determination to success to overcome cancer by consuming nanogold and nanosilver. This self-efficacy influences a feeling of their determination to success. This research employs method of qualitative, along with collecting data through interviews, observation and documentation. Interviews were conducted on volunteers in the cancer museum with 10 people, which consist of 1 doctor, 7 volunteers and 1 cancer patient. Collecting data is undertaken through two stages. The first is a focused interview. The second is to provide questionnaires. Following data collection, subsequently the questionnaire was revised to complete their explanation with documents collected from the literature and cancer museum. The results of the snowball sampling analysis employed in this process shows that the characteristics of people who have highly confidence are indicated by their readiness to find out information from doctors, internet sources, and information from the cancer museum, as well as persistence in consuming nanogold and nanosilver. Moreover, mental readiness is required to bring a cancer patient to accept the live whatsoever. Spirituality and religiosity sway the patient to belief in the success during the treatment consuming nanogold and nanosilver. By such a mental, the medication is considered as an effort with strong belief on God's assistance and blessing during which it strengthen the mental of the patient.