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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24).We retrospectively analyzed 46 patients with FL admitted to Teikyo University Hospital and treated with chemo-immunotherapy between May 2009 and July 2019. Physical characteristics, blood parameters, and markers or scores for consumptive/ inflammatory and nutritional conditions were used as variables.Nine parameters correlated with poor overall survival (OS) in univariate analysis: An Eastern Cooperative Oncology Group (ECOG) scale performance status (PS) ≥2, five or more involved nodal sites, positive bone marrow (BM) involvement, a serum albumin level <3.5 g/dL, CRP >0.5 mg/dL, lactate dehydrogenase (LD) higher than the upper normal limit (UNL), high-density lipoprotein cholesterol (HDL-C) <40 mg/dL, modified Glasgow prognostic score of 1-2, and the geriatric nutritional risk index <82. In multivariate analysis, ECOG PS ≥2, positive BM involvement, and a serum HDL-C level <40 mg/dL remained significant for poor progression-free survival. One-year OS rate after receiving salvage chemotherapy was lower in the POD24 group (50%) and POD24 correlated with ECOG PS ≥2, positive BM involvement, a serum lactate dehydrogenase >UNL, and HDL-C <40 mg/ dL by Fisher's exact test.These results indicate that low serum HDL-C levels appear to be important for predicting the risk of POD24 and the worse prognosis of FL.Abbreviations: Auto = autologous hematopoietic stem/progenitor cell transplantation, BG = bendamustine and obinutuzumab, BM = bone marrow, BR = bendamustine and rituximab, CI = confidence intervals, CONUT = the controlling nutrition status, CR = Complete remission, CRP = C-reactive protein, CT = computed tomography, DLBCL = diffuse large B-cell lymphoma, ECOG = Eastern Cooperative Oncology Group, FL = follicular lymphoma, FLIPI = follicular lymphoma international prognostic index, GELF = Groupe d'Etude des Lymphomes Folliculaires, GNRI = the geriatric nutritional risk index, HDL-C = high-density lipoprotein cholesterol, HR = hazard ratios, HSCT = hematopoietic stem/progenitor cell transplantation, LD = lactate dehydrogenase, LDL-C = low-density lipoprotein cholesterol, mGPS = the modified Glasgow prognostic score, NHL = non-Hodgkin's lymphoma, OS = overall survival, PFS = progression-free survival, PNI = the prognostic nutritional index, POD = progression of disease, POD24 = progression of disease within 24 months of first-line chemo-immunotherapy,