Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel beta-coronavirus that causes a variety of symptoms in patients known as coronavirus disease (COVID-19). COVID-19 infection may cause complications involving the central nervous system (CNS), peripheral nervous system (PNS), muscles, or autonomic system (ANS). Compared with central and peripheral nervous system involvement in COVID-19 infection reports, the bibliography describing ANS manifestations is more limited. We report a patient with confirmed SARS-CoV-2, admitted to one of the tertiary hospitals in Singapore with small fiber neuropathy. Small fiber neuropathy as a neurological manifestation in COVID-19 infection is rare. Our case report adds to and supports this observation and also highlights how SFN in COVID-19 infection can be self-limited without requiring immunosuppressive treatment.
main/index). Patients consented are prospectively entered using online forms for baseline and subsequent visits. Data collected includes demographics, diagnosis, medical history, modified Rankin Score (mRS), Glasgow Coma Scale (GCS), National Institute of Health Stroke Scale (NIHSS), compliance and side effects.
ResultsFifty-eight patients from Slovakia, Macedonia and Poland were included with mean age of 62.04 ± 11.48 years, with 23 (39.66%) women. NurAiD II was started at 100.45 ± 225.95 days since the time of stroke onset. Median NIHSS for the patients was 9 (1-33) at baseline (B), 6.0 (0-19) at M (month) 1, 5 (0-42) at M2 and 3 (0-42) at M3 (Fig. 1). mRS was improving over time (Fig. 2). No side effects were reported. 2 patients died due to causes deemed not related to NurAiD II.
ConclusionsNurAiD II was safe in ischemic stroke in the Eastern European population who improved on functional, neurological and cognitive measures.
Presently, thermal comfort requirements are increasing at a faster rate. Several technologies are available in market to choose from. A cost benefit analysis of technologies is always helpful from the consumer point of view to select the correct cooling system. It is very important to note that energy and environmental assessments are also necessary to be considered along with economics. Hence this work is carried out to propose a clear picture of comparison between two mostly used air-conditioning systems i.e. fixed speed split air conditioning system and variable refrigerant flow system. It is proved that variable refrigerant flow system is advantageous over conventional fixed speed split air-conditioning system. However, it is also noted that small households and shops did not found this appropriate due to high fixed cost and maintenance cost. This work is made to compare the above mentioned systems for different capacities and number of operating hours, keeping nature of load as similar under standard ambient condition. The main variables are system capacity, working hours, years of operation, total cost (initial cost +operational cost+ maintenance cost), power saving, life span, space saving etc. The Results shows that hours of usage dominates over sizing of the unit on the basis of energy, economic and environmental analysis.
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