In this paper, we study a new approach for solving linear fractional programming problem (LFP) by converting it into a single Linear Programming (LP) Problem, which can be solved by using any type of linear fractional programming technique. In the objective function of an LFP, if β is negative, the available methods are failed to solve, while our proposed method is capable of solving such problems. In the present paper, we propose a new method and develop FORTRAN programs to solve the problem. The optimal LFP solution procedure is illustrated with numerical examples and also by a computer program. We also compare our method with other available methods for solving LFP problems. Our proposed method of linear fractional programming (LFP) problem is very simple and easy to understand and apply.

Kallmann syndrome (KS) is a rare genetic disorder characterized by hypogonadtrophic hypogonadism associated with altered sense of smell. KS is due to failure of intrauterine migration of olfactory axons and gonadotropin releasing hormone (GnRH) neurons from olfactory plate to the hypothalamus. There is defective hypothalamic gonadotropin releasing hormone (GnRH) synthesis and agenesis or hypoplasia of olfactory bulbs and olfactory sulcus.The prevalence is estimated at one in 10,000 males and one in 50,000 females. We described a case of 22 years male patient who presented with delayed puberty, characterized by absence of facial and axillary hair and sparse pubic hair, micropenis and bilateral small testes and associated with decrease smelling capacity. Diagnostic evaluation consist of hormonal evaluation which revealed revealed low levels of testosterone, LH & FSH with normal levels of TSH, prolactine and cortisol. MRI shows agenesis of olfactory bulbs and grooves, absence of the olfactory sulcus resulting in fused gyrus rectus and medial orbital gyrus forming a single gyrus. Furthermore, this patient had partial empty sella, which is one of the anomalies that are associated to this syndrome. It is planned to manage this case with Hormonal replacement therapy to induce puberty and later on pulsatile GnRH will be administered when fertility will be desired.

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Background: Left ventricular (LV) filling pressure is an important predictor of short and long term outcome in patients with coronary artery disease. Non invasive assessment of this pressure by Doppler echocardiography provides valuable information regarding the prognosis of patient with ST-segment elevation myocardial infarction. Elevated filling pressure is associated with increased incidence of morbidly and mortality due to ventricular remodeling, neuro-hormonal activation & increased excitability. The aim of this study was to assess LV diastolic dysfunction and left ventricular filling pressure in patients of ST-segment elevation myocardial infarction to predict their in-hospital outcome. Methods: The prognostic cohort study was conducted in National Institute of Cardiovascular Diseases, Dhaka from May 2011 to November 2011. A total of 100 Patients with acute ST-segment elevation myocardial infarction who has received streptokinase therapy were enrolled by purposive sampling. In addition to normal 2D & M mode study, Pulsed wave Doppler assessment of mitral valve inflow patterns was done in apical 4-chamber view to see Peak early (E) and peak late (A) flow velocities, E/A ratio and deceleration time of early mitral flow velocity (DT). Tissue Doppler Imaging (TDI) assessment was done at the lateral mitral annulus in apical 4-chamber view to assess Mitral annular diastolic velocity (E?) and E/E? ratio. Patients were divided into two groups based on Doppler echocardiography derived Left ventricular filling characteristics. In group I 50 patients with E/E? ratio <15 and in group II 50 patients with E/E’ >15. Patients were followed up for next 7 days and in-hospital outcomes were compared between groups. Results: The mean age of group-I & II were 53.84 ± 9.2 & 55.14 ± 8.5 years respectively. Male female ratio was 8.9:1.1. Age, sex and risk factors between two groups were statistically insignificant. Regarding in-hospital out come in group-I were hospital stay 5.28 ± 1.06 days, heart failure 28%, arrhythmia 8% and mortality was 2%. On the other hand in group-II hospital stay was 6.04±1.07 days, heart failure 68%, and arrhythmia 24% & mortality was 6%. All these were statistically significant between two groups except mortality. Conclusion: From this study it may be concluded that, left ventricular filling pressure assessed by Doppler echocardiograph predicts in-hospital outcome after acute ST segment myocardial infarction and prognosis is worse with increased left ventricular filling pressure. DOI: http://dx.doi.org/10.3329/cardio.v7i2.22244 Cardiovasc. j. 2015; 7(2): 72-78

Tuberous sclerosis is a complex disorder which has multisystem involvement and varied clinical manifestations. Almost half of the patients have associated angiomyolipoma which contains fat, vascular and smooth muscle components. Spontaneous pseudoaneurysm formation is a complication of angiomyolipoma. Here we present a case of a female child presenting with hematuria who after thorough clinical and radiological investigations was diagnosed as a case of tuberous sclerosis with right intrarenal pseudoaneurysm. She was successfully treated with endovascular coil embolization.