The search for prompt, less toxic and economically affordable medical therapy has facilitated the increased investigation into the therapeutic potentials and applications of plants samples against common tropical ailments. This study was designed to investigate the reported link between experimental type II diabetes mellitus (T2DM) and neurocognitive decline and the justification for the use Alstonia boonei leaf in similar treatments. Experimental T2DM were treated with 100, 1000 and 1600 mg/kg BWT of the Alstonia boonei leaf and glibenclamide (100 mg/kg BWT). Biochemical analyses were used to determine effects on the pancreatic and neuronal indices of tissues functions; oxidative stress; excitation; and inflammation; blood glucose and insulin concentrations. The study revealed that T2DM and Alstonia boonei leaf affected the activity of tyrosine hydroxylase which is the regulating enzyme for the biosynthesis of dopamine. The oxidative and inflammatory stress exacerbated by T2DM was mitigated by a significant reduction of TNF-α and an increase of GSH, NP-SH, GPx, SOD and GST levels. Alstonia boonei leaf reversed the insulin resistance by the cells, with effective transduction of insulin signal and a corresponding reduction of circulating glucose. Alstonia boonei leaf demonstrated hypoglycaemic effect, and mitigated the neurodegeneration that ensued from the diabetic induction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.