Pneumatosis cystoides intestinalis (PCI) is a rare disease characterized by presence of multiple gas filled cysts in subserosal or submucosal wall of large intestine or small intestine. PCI are most commonly due to an underlying disease or can be idiopathic. Understanding of etiology and pathogenesis is necessary in each individual case for appropriate management. Thirty eight enteral resected specimens were studied from January 2008 to September 2011 in PESIMSR. Clinical and morphological characteristics of the 3 cases with histological diagnosis of PCI found, were studied and compared with other studies.

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Multisystem Inflammatory Syndrome in Children (MIS-C) is a newly recognized multiorgan disease seen in children, adolescent and young adults presumed to be a delayed immune mediated complication of Corona virus 2 (SARS-CoV-2) infection leading to severe acute respiratory syndrome. MIS-C can be associated with life threatening organ dysfunction requiring complex multidisciplinary care. Early recognition is important in order to prevent complication and serious sequalae. Because it is a post infective complication, in most of the cases RT-PCR comes negative though antibodies to COVID-19 are positive. Although SARS-CoV-2 in children are generally mild and nonfatal, there is increasing evidence of MIS-C. Clinical and laboratory features of MIS-C are similar to those of Kawasaki disease like syndrome and Toxic Shock Syndrome. Pathophysiology of MIS-C is still unclear and mainly due to formation of autoantibody and immune complex which activates inflammation. Most of the MIS-C associated with COVID-19, need treatment with ionotropic agents and anticoagulants. The long-term outcome of MIS-C like coronary artery aneurysm formation remain unknown and needs close follow up.