Abstract-For the performance-efficient integration of IPs on an SoC utilizing heterochronous multi-clock domains, we propose a synchronization scheme that causes low latency overhead when data are crossing clock boundaries. The proposed synchronization scheme is composed of a clock predictor and a synchronizer. The clock predictor of a sender clock domain produces a predicted clock that is used in a receiver clock domain to detect possible synchronization failures in advance. When the possible synchronization failures are detected, a synchronizer at the receiver delays data-capture times to avoid the possible synchronization failures. From the simulation of the proposed scheme through SPICE modeling using a Chartered 0.18 mm CMOS process, we verified the functionalities and timing behavior of the clock predictor and the synchronizer. The simulation results show that the clock predictor produces a predicted clock before a synchronization failure, and the synchronizer samples data correctly using the predicted clock.