A 50‐year‐old Korean man had an erythematous patch on the left side of his chest since birth ( Fig. 1). We first regarded this lesion as nevus flammeus because of the resemblance of the lesion to an erythematous patch that blanched with pressure. Physical examination revealed an 8×5 cm erythematous patch with a central profuse sweating zone surrounded by a flame‐like non‐sweating zone ( Fig. 2). The patch was sharply demarcated from the normal skin. Sweating was evoked by physical exercise or emotional stress. There was no history of pain or tenderness for the lesion. The patient had no history of any other vascular disease. Histopathologic examination of the central zone showed an increased number of eccrine glands in the mid and deep dermis. Some dilated vascular channels that were not associated with the eccrine glands were present in the upper dermis and subcutaneous tissue ( Fig. 3). Immunohistochemical stain with anti‐factor VIII‐related antigen showed reactivity on the endothelia of the vascular elements which were not associated with eccrine glands in the upper dermis. Histopathologic examination of the surrounding zone showed non‐specific findings, except for the dilated vascular channels in the upper dermis. 1 (A) hyperhidrotic erythematous patch on the left side of the chest 2 (A) sharply demarcated 8×5 cm erythematous patch with a central profuse sweating zone surrounded by a flame‐like non‐sweating zone 3 Several eccrine angiomatous lobules in the mid and deep dermis, and hyperplasia and dilation of vascular structures in the upper dermis and the subcutaneous fat (hematoxylin and eosin, ×100)

Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is toxic against transformed tumor cells. Cornification is the terminal differentiation of keratinocytes and a specific form of programmed cell death caused by TRAIL that occurs in keratinocytes. Apoptosis can also be triggered when TRAIL induces expression of keratinocyte differentiation markers. The present study reported that hypoxia inhibits TRAIL‑induced apoptosis due to autophagic flux. It is well known that hypoxia activates autophagy in keratinocytes and reduces p62 protein levels. The present study demonstrated that hypoxia inhibited TRAIL‑mediated apoptosis and induced autophagic flux in HaCaT cells. In addition, autophagic flux‑inactivating reagents, including 3‑methyladenine and chloroquine, increased the TRAIL sensitivity of HaCaT cells exposed to hypoxia. In conclusion, these results indicated that inactivating autophagy increased TRAIL sensitivity in hypoxic HaCaT cells. Autophagy inhibitors may be beneficial in therapies using TRAIL against skin cancers.

Many volcanic craters and calderas are filled with large amounts of water that can pose significant flood hazards to downstream communities due to their high elevation and the potential for catastrophic releases of water. Explosive volcanic activity, uplift of the lake floor and landslides directed into the lake are some of the possible scenarios that can cause the release of water through a breach. In this paper, we derive a physically based model that uses the mass balance equation to simulate the hydrograph through a breached rim due to water displacement by lake floor uplift or landsliding. The model was applied to the Baekdusan volcano to examine its performance. Then, the hydrograph at the breach of a caldera lake serves as an upstream boundary condition for the subsequent flood‐routing model, FLO‐2D. The FLO‐2D simulation shows that three populated towns are at risk, showing maximum depth up to 10–30 m. The flow converges to the Baishan dam that has a volume capacity of 6.5 km3. The simulation shows the probable inundation zones and maximum depth, and these are to be used for risk assessment.

The Front Cover shows the porous dendrite structure of CuCx–Cu and NiCxNi that can be used as cost‐efficient bi‐functional catalysts instead of Pt and RuO2 catalysts in Zn–air batteries. Although many research efforts have been devoted to developing alternative electrocatalysts to noble‐metal catalysts, the obtained catalysts are only highly active for either the oxygen reduction reaction (ORR) or the oxygen evolution reaction (OER). By introducing a stable metal‐carbide layer on a dendritic metal structure, we managed to prepare a catalyst with a high catalytic surface and an appropriate oxygen binding energy that can be use as bifunctional catalyst in Zn–air batteries. More information can be found in the Communication by Kim et al. on page 4203 in Issue 24, 2018 (DOI: 10.1002/cssc.201802122).