IV, case series, treatment study.

Abstract-Using growth factors to induce vasculogenesis is a promising approach in the treatment of ischemic legs and myocardium. Because the vasculogenesis requires a cascade of growth factors, their receptors, and intracellular signals, such therapies may require the application of more than a single growth factor. We examined the effect of 2 endothelial cell-specific growth factors, angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF), on primary cultured porcine coronary artery endothelial cells. VEGF, but not Ang1, increased DNA synthesis and cell number. Ang1 or VEGF induced migration and sprouting activity, increased plasmin and matrix metalloproteinase-2 secretion, and decreased tissue inhibitors of metalloproteinase type 2 secretion. A combination of the submaximal doses of Ang1 and VEGF enhanced these effects and was more potent than the maximal dose of either alone. In a rabbit ischemic hindlimb model, a combination of Ang1 and VEGF gene delivery produced an enhanced effect on resting and maximal blood flow and capillary formation that was greater than that of either factor alone. Angiographic analyses revealed that larger blood vessels were formed after gene delivery of Ang1 or Ang1 plus VEGF than after VEGF gene delivery. These results suggest that combined treatment of Ang1 and VEGF could be used to produce therapeutic vascularization. (Arterioscler

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ease of fabrication and good performance the proposed ZOR may find applications in wireless communication systems. IEEE Trans Microwave Theory Tech 61 (2013) 9. D.K. Upadhyay, S. Pal, An improved zeroth order resonator using left handed metamaterial, J Microwaves Optoelectron Electromag Appl 12 (2013), 131-140. 10. M.A. Abdalla and Z. Hu, Design and analysis of tunable left handed zeroth-order resonator on ferrite substrate, IEEE Trans Magn 44 (2008), 3095-3098. 11. C. Caloz and T. Itoh, Electromagnetic Metamaterials: Transmission Line Theory and Microwave Applications, 2nd ed., Wiley and IEEE Press, Hoboken, NJ, 2005 12. M.M. Mansour, M. El-Mala, A.-A.T. Shalaby, E.S.M. El-Rabaie, N.W. Messiha, CRLH ZOR metamaterial, design, simulation and fabrication. Guang-ming and L. lian-gang, Novel zeroth-order resonator antenna based on composite right/left handed (CRLH) transmission line, Cross Strait Quad RegionalABSTRACT: A printed microstrip line-fed fractal antenna is presented with a high fidelity factor for UWB applications. The antenna structure of electrical dimension 0.24 k 3 0.33 k at lower frequency 3.1 GHz is made of a fractal patch, a slotted partial ground plane, and a microstrip feed, which is fabricated on FR4 material of low cost and dielectric. Measured results demonstrates that the fractal antenna achieves fractional bandwidth of 117.88% covering the frequency range from 3.1 GHz to more than 12 GHz with a maximum gain 3.54 dBi at 6.25 GHz. An acceptable analogy is observed between measured and simulation results. The high fidelity factor, sharply surface current distribution, time domain performances, acceptable gain, and nearly omnidirectional radiation characteristic have validated the appropriateness of this proposed fractal antenna for UWB and microwave imaging applications.ABSRACT: A method has been proposed to increase the size of rectangular microstrip patch antenna (RMPA) for mm-wave and terahertz frequencies to increase the fabrication tolerance. The method is experimentally tested on a RMPA designed at 56 GHz frequency where both the simulation and measured results are in good agreement. Moreover, the antenna's overall performance is also improved.