No abstract

The rapid growth of web information and its services in different areas such as e-commerce, healthcare, digital marketing, online booking, etc. is a challenge in providing accurate information in the domain services related to the user's query. The current web information of services classifies the retrieval of the relevant service and assists the classification by supporting the knowledge and classifications of the specific service information. Because of these limitations and the complexity of automatic update mechanisms to see this service information, a large number of non-related service information for a requested query, and getting the required web information of services is a cumbersome problem. This paper proposes Semantic based Terms Relation Approach (STRA) for classifying information for effective classification of WIS on the web. The approach utilize Concept Terms Similarity (CTS) method for the most relevant terms in a service domain and construct a Related Terms Hierarchal Model (RTHM), which will be used for classification. A modified Naive Bayes classifier is used to perform the classification of the web information of services using RTHM, to categorize and present accurately. The experiment evaluation of the proposed approach shows an improvement in the classification of information and achieve a highly related matching results against different number of users queries.

The current study entails novel advanced formulation approach binary ethosomal gel containing Carvedilol and evaluating the optimized formulation for hypertension. Carvedilol is an antihypertensive agent, which undergoes hepatic metabolism and shows poor bioavailability of just 20 %. Carvedilol binary ethosomal suspension was optimized using central composite design (CCD). In which quantities of lipid (A), ethanol (b), and propylene glycol (C) were selected independent variables; vesicle size (Y1), entrapment efficiency (Y2) and cumulative %drug release (Y3) were selected as dependent variables. The composition of optimum formulation was found as 2 % of lipid (Soya lecithin), 20 % of ethanol, and 10 % of propylene glycol. The optimized binary ethosomal suspension (OBE) had shown a vesicle size, poly dispersable index, ztapotential, cumulative % drug release, and %entrapment efficiency of 130±1.72nm, 0.230±0.03,-31±1.8MV, 97.89±3.7 %, and 99±2.96 % respectively. This was further evaluated and compared with liposomes. Scanning electron microscopy studies revealed that OBE was in spherical shape. The OBE was converted to hydrogel and evaluated for rheological properties. The OBE-Gel (OBE-G) attained mean transdermal flux of 0.0644±0.002 mg/cm 2 .h through rat skin. This formulation showed a substantial and constant decrease SciForum in blood pressure, for up to 24 h. The OBE-G was found to be effective, with reduction in blood pressure by virtue of better permeation through rat skin. In conclusion, OBE-G accentuate the transdermal flux and the results obtained encouraged its use for hypertension treatment.