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A mononuclear copper(II) complex [Cu II (L)(fu) 2 ] (1) [L ¼ 2-(2-pyridyl)benzimidazole, fu ¼ furoate] has been synthesized and characterized by X-ray crystallography. Structural analysis reveals that 1 adopts a distorted square pyramidal geometry with CuN 2 O 3 chromophore. Spectrophotometric and hydrodynamic investigations suggest that the complex binds with DNA in an intercalative mode with a binding constant of (3.19 AE 0.32) Â 10 4 M À1 . 1 induces oxidative cleavage of the supercoiled DNA to its nicked circular as well as linear forms. 1 is also proved to be an anti-cancer agent on human keratinocyte cells.

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