Background: Methicillin resistant Staphylococcus aureus (MRSA) infections are important causes of morbidity, mortality in hospitals and the community worldwide. MRSA has been known to acquire resistance to most antibiotics like β-lactams and aminoglycosides so these strains are more virulent. Aims and Objectives: Therefore the knowledge and determination of prevalence of MRSA and their current antimicrobial profile becomes necessary to the clinicians to avoid clinical complications from community-acquired and hospital acquired MRSA infection. Materials and Methods: A total of two hundred five different samples from different clinical specialties were collected and processed by appropriate microbiological technique like staining, culture, biochemical test and antimicrobial susceptibility test by the use of different antibiotic discs. Results: The present study shows that 47 MRSA strains out of 105 men comprising 44.76%, whereas in case of females it was 29% i.e, 29 MRSA strains out of 100 cases. MRSA percentage of males was higher than the MRSA percentage of female. It proves that men were more prone to acquire the infection by MRSA strain. Out of 205 clinical samples, 76 were identified as MRSA so the prevalence rate was 37.07% but all the multidrug resistance MRSA were mostly sensitive towards antibiotics like Vancomycin (100%), Rifampicin (100%), Amoxicillin (77.77%) and Amikacin (61.19%). Conclusion: In conclusion, vancomycin could be considered for treatment to eradicate the MRSA.