Background and Purpose— Mechanical thrombectomy may involve multiple attempts to retrieve the occluding thrombus. This study examined the composition of thrombus fragments retrieved with each pass of a device during the thrombectomy procedure. Second, the per-pass composition was compared with procedural and clinical data including angiographic outcome and stroke etiology. Methods— Thrombi were retrieved from 60 patients with acute ischemic stroke, where thrombus fragments retrieved in each pass were segregated as individual samples and maintained throughout the histological analysis as independent samples. All samples were stained with hematoxylin and eosin and Martius Scarlet Blue. The relative composition of red blood cells, fibrin, and white blood cells in thrombus fragments from each pass was quantified. Results— Over the 60 cases, thrombus material was retrieved in 106 of 138 passes. The number of passes required to complete the cases ranged from 1 to 6 passes. The analysis of thrombus fragments retrieved in each pass provided a greater insight into the thrombectomy procedure progression than the overall thrombus composition; the red blood cell content of thrombus fragments retrieved in passes 1 and 2 was significantly higher than that retrieved in passes 3 to 6. The removal of thrombus material in a total of 1, 2, or 3 passes was associated with the highest percentage of final modified Thrombolysis in Cerebral Infarction score of 2c-3. There was no association between modified Thrombolysis in Cerebral Infarction score and per-pass thrombus composition. Conclusions— The differentiation achieved through the per-pass analysis of acute ischemic stroke thrombi provides a greater insight into the thrombectomy procedure progression than the combined per-case thrombus analysis. Insights gained may be a useful consideration in determining the treatment strategy as a case evolves and may be useful for the development of new devices to increase rates of 1-pass recanalization.

Subcutaneous human dirofilariasis is caused by the zoonotic filariae Dirofilaria repens. The frequency of reports is increasing in literature during the last few years and is considered by some authors as an emerging zoonosis. Here we report 21 cases of subcutaneous dirofilariasis, which were encountered over a period of 8 years. None of these cases were associated with peripheral eosinophilia. Since these lesions can mimic benign and malignant tumors, it is important to consider this as a differential diagnosis of subcutaneous nodules especially in an endemic area. In this report we would like to emphasize the importance of studying multiple deeper levels in suspected cases of parasitic granuloma to demonstrate the parasite.

Background: Phaeohyphomycosis is a subcutaneous or systemic infection characterized histologically by dark-colored fungal hyphae. With the increasing number of immunocompromised patients, the incidence of the disease has increased recently. The objective of the study is to emphasize the role of histopathology in the diagnosis of phaeohyphomycosis. Methods: The biopsy specimens of seven cases of subcutaneous phaeohyphomycosis were examined using routine and special stains. The clinical presentation in these cases was also evaluated. Results and Conclusions: Diagnosis was made in all cases by demonstration of fungal structures. Histopathology is an important tool in the diagnosis of phaeohyphomycosis. Phaeohyphomycosis should be considered in the differential diagnosis of suppurative granulomatous inflammation presenting as subcutaneous nodules. Fine needle aspiration cytology can also be used as a diagnostic method.

Angioleiomyomas are benign mesenchymal tumours commonly occurring in the subcutis of extremities. They are typically composed of interlacing fascicles of smooth muscle cells with intersecting vascular channels. Angioleiomyomas of the uterus are rare with only very few case reports available in literature. Herein, we report a case of this rare entity in a 47-year-old woman owing to its highly unusual features of cellular atypia, raised CA-125 levels, and pseudo Meigs syndrome.

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