Introduction: There have been multiple variants of Severe acute respiratory syndrome coronavirus 2 (SARS CoV- 2), a strain of coronavirus, that causes COVID-19, a respiratory illness responsible for the ongoing COVID-19 pandemic, since its first identified outbreak in Wuhan, China in November 2019. Since the pandemic began there have been various changes in the isolation period of the identified cases reducing from 2 to 3 weeks to the current recommendation of 5 days of isolation in symptom-free individuals in various countries. As of July 2022, only the Omicron variant has been identified as a variant of concern by the World Health Organization.   Method: Articles were searched in Google scholar, PubMed, CDC guidelines, NHS guidelines (UK), Indian guidelines (Ministry of Health and Family Welfare), Nepal guidelines (Ministry of Health and Population), and WHO guidelines.   Result: The guidelines recommend a self-isolation period of infected individuals ranging from 5 to 14 days after testing positive for the COVID-19 disease.   Conclusion: COVID-19 is here to stay and showing no signs of slowing down though overall fatality rate have been on decline owing to vaccination and increased immunity against the virus, it is ideal to shorten the duration of isolation and focus on protection against the virus all the times and not letting the guard down.

Transient ischemic attack (TIA) is commonly presented at the emergency department as transient and nonspecific symptoms, which are difficult to localize and interpret. It is often required to have strong clinical suspicion to diagnose TIA. Optimal blood pressure control is of utmost importance to minimize hazardous consequences of TIA and stroke. There have been many scoring systems to predict stroke after TIA but none of them are reliable to access low or high risk for early recurrent stroke. There is emerging evidence among association between high D Dimer level and acute ischemic stroke followed by TIA but a dose-dependent relationship between D-dimer and the risk of stroke is yet to be established. Until now neuroimaging has been the investigation of choice for detecting TIA and stroke.