The asymmetric reduction of ketones catalyzed by chiral titaniumc omplex, prepared in situ from titaniumt etraisopropoxide and aC 2 -symmetrical chiral hydroxyamide, with catecholborane as the reducing agent afforded the corresponding chiral secondary alcohols in good yields with high enantioselectivity of up to > 99 % ee.

No abstract

An in situ generated chiral titanium catalyst and catecholborane as reducing agent are employed for the reduction of ketones to give the corresponding alcohols with up to < 99% e.e.