Achromobacter xylosoxidans , also known as Alcaligenes xylosoxidans , is a low-virulence, non-fermenter gram-negative bacillus mainly found in marine environments. We report a detailed series of four high-risk cases of septicemia with the common variable of positive blood cultures for A. xylosoxidans . All four blood isolates were multi-drug resistant and susceptible to meropenem and trimethoprim-sulfamethoxazole. Two patients responded well to the treatment with meropenem and trimethoprim-sulfamethoxazole and two patients died. It should never be assumed that Achromobacter is a contaminant even though it is relatively infrequently isolated from clinical samples. This infection can progress to fatal bacteremia, even in otherwise healthy people, and it can potentially cause severe conditions in premature infants. With only a limited number of antibiotics demonstrating bactericidal properties, the possibility of failure in empirical treatment is significant. As a result, it is important to have a precise comprehension of this uncommon yet deadly illness in order to increase the probability of successful treatment.

Background: COVID-19 is an infectious disease caused by the newly acquired SARS-COV2 virus. The disease is rapidly changing, as well as our understanding of the emerging virus. Not knowing what it was at the beginning of the year 2020, scientists have been able to classify, track, classify, and establish diagnostic tests. Severe illness may strike the elderly and those with chronic illnesses, such as heart disease, diabetes, or cancer. Conclusion: Over the past four decades, the emergence of new infectious, global threats has reshaped national and international thinking and the level of public health responses needed to combat these threats. All countries are at risk of new diseases, according to International Health Regulations.

A Gram-positive spore forming bacilli, aerobe or facultative anaerobe is . It is ubiquitous which disperse in the environment. is a potential pathogen accountable for fulminant human infectious disease and hardly ever contribute to eye infections. A 35-year-old farmer came to ophthalmology OPD on February 2019, and the patient complained of acute onset left eye pain with diminution of vision. There was history of eye injury by the vegetation (thorn). There was presence of corneal ulcer. The patient was not immunocompromised.Corneal scrapping was collected from left eye. On Gram staining from corneal scrapping only two Gram positive bacilli, with occasional pus cell and fibrinous exudate was seen. Culture on blood agar medium it showed beta haemolytic, about 2-5 mm in diameter, big flat, irregular edges and greyish white colonies which were oval, slightly granular but not dry. On Mac -Conkey agar medium it showed non lactose fermenting, big flat, irregular colonies.From colonies Gram staining showed Gram positive bacilli with spore. They were motile, catalase positive, oxidase positive, reduced nitrate to nitrite and were resistant to penicillin. The identification was also confirmed by Vitek. This case highlights the importance of cultivation, detection and antibiotic susceptibility test rather than treating patients with ocular infection empirically.

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