Our initial findings around aryl sulfonamide series led to N-(3,5-dichloro-2-methoxyphenyl)-3-(1-methylpiperidin-4-ylamino)-4-methoxy benzenesulfonamide as potent and selective 5-HT(6) receptor (5-HT(6)R) antagonist with reasonable pharmacokinetic properties and activity in animal models of cognition. However, lack of brain penetration and P-glycoprotein liability makes this scaffold unsuitable for further development. Our goal was to identify small molecule 5-HT(6)R antagonist with adequate brain penetration, acceptable ADME properties, no P-glycoprotein, and no hERG liability. Several structural modifications including bringing conformational constraint around the sulfonamide -NH group and introduction of a heteroatom to modulate the physicochemical properties were attempted. This effort culminated in the discovery of series of novel, potent, selective, orally bioavailable, and adequately brain penetrant compounds with no hERG liability. These compounds showed activity in animal models of cognition like object recognition task and water maze and in brain microdialysis studies at lower doses.

The research work proposes, Design and implementation of Solar power fed permanent magnet synchronous motor using improved DC-DC Converter and modified p-q theory based shunt active filter for reducing vibrations in drive for Industrial Applications. The Proposed research consists of both buck and boost converter, linking dc voltage unit and works in discontinuous conduction for boosting the battery life time. The improved converter provides multiple output capability using B4-inverter which reduces the cost of a proposed system considerably. In addition, for the reduction of harmonics in three phase system modified p-q module is enhanced. Comparing with the existing module, modified p-q module act as a triggering module for inverter to reduce harmonics in three phase systems and vibration across the motor, moreover the structured circuit would result in reduction of total harmonic distortion (THD), torque ripples, compact power switches, DC source reckoning and reduced starting current. The simulation of buck boost converter is considered, and its performance parameters were analyzed for different operating conditions. Thus, for industrial applications, the bidirectional converter and inverter fed permanent magnet synchronous motor drive is employed with the reduction in vibration, which is more efficient than conventional method. Here both simulation and experimental setup has been employed with a satisfying closed loop performance.

The proposed research involves the design and implementation of a novel hybrid Topology for Power Quality Improvement using Multilevel Inverter to reduce vibration and noise in BLDC motor for industrial applications. The utility of power electronics device plays a vital role for various applications in recent days. Similarly, the power consumption is also important for all processing units. The power electronic devices contain a lot of converters for processing the energy. During such cases, the harmonics are produced in different ways. Hence, a system analysis is necessary to find the problem at conventional methods. Hence the problem is identified on the distribution static compensator (DSTATCOM) component module whose harmonics are high, and it is important module for the circuit, hence preventive action to be taken to reduce the harmonics. To limit or reduce the harmonics, it is required to modify the triggering mechanism and control unit of Multi level inverter. Hence, the proposed hybrid method is implemented with the developed H-bridge and diode clamped topology with a brushless dc motor. In addition, the vibrations and the noise level are also reduced due to the reduced total harmonic distortion. The proposed module is simulated on MATLAB Simulink, and an experimental analysis is carried out to verify functionality tools with various operating conditions, the proposed method proves more efficient than the switches and complex networks present in traditional methods.