Background and Objectives: The present study is conducted to compare the anti-microbial efficacy of tooth paste containing lactoferrin, lysozyme, lactoperoxidase (BioXtra ®), a 500ppm fluoride tooth paste, and a non fluoridated tooth paste in children with Severe Early Childhood Caries (S-ECC). Materials and Methods:Study group included 30 children with S-ECC aged 3-5 years. Subjects were randomly selected & divided into three groups of ten each. Group I: Non-fluoride tooth paste, Group II: 500 ppm fluoride tooth paste, Group III: tooth paste containing lactoferrin, lysozyme & lactoperoxidase. Estimation of salivary S. mutans and L. acidophilus levels was accomplished by collecting salivary samples and inoculated on Mitis Salivarius Bacitracin agar (MSB) and Rogosa SL media. Colony Forming Units (CFUs) were counted and the results were tabulated and subjected to statistical analysis. Results:Brushing with tooth paste containing lysozyme, lactoferrin and lactoperoxidase after a week showed highly significant reduction in the CFU counts of both salivary S. mutans and L. acidophilus (p<0.001), whereas 500ppm fluoride tooth paste showed a highly significant reduction in the S. mutans levels (p<0.001), but a significant reduction in L. acidophilus count (p<0.01). Non-fluoride tooth paste showed a highly significant reduction in S. mutans (p<0.001) only, but reduction in the L. acidophilus levels was insignificant (p<0.05). Conclusion:The present study revealed that tooth paste containing lactoferrin, lysozyme, and lactoperoxidase was highly significant in reducing the salivary levels of mutans Streptococci and L. acidophilus in children with S-ECC.

Introduction: Benzydamine hydrochloride is an NSAID most often used in radiation induced oral mucositis. The indazole analogue benzydamine has physical,chemical, and pharmacological properties which differ from those of the aspirin-like NSAIDs. Benzydamine specifically act on the local mechanisms of inflammation, granuloma, and exudate. Methodology: The study was a double-blinded, randomized, controlled clinical trial. A total of 30 chronic periodontitis patients reported to the dental hospital were selected for the study using a purposive sampling technique. Thirty chronic periodontitis patients scheduled for periodontal surgeries were randomized to receive either Benzydamine hydrochloride Mouthwash (MW) or Diclofenac Tablets (TB), post-surgery. The MW group patients were advised to rinse with undiluted 15 ml solution for 60 secs, 2-5 times daily for three days. TB group were asked to take 50 mg tablet twice daily for three days. A 10-point Visual Analog Scale (VAS) and Wong-Baker Facial Rating Scale (FRS) were recorded to measure the pain perception by the patients.Gingival status was assessed by the Modified Gingival Index (MGI) at baseline and seventh day. Results: Intra-group comparison of pain values at day 1 and day 2 in both VAS and WONGBAKER scales demonstrated significance for the mouthwash group, suggesting more efficacy than the tablet group. Inter-group results showed statistical significance in both groups in relief of pain (p<0.05). Intra-group comparison results for both groups signified the superior efficacy of the mouthwash with p-values 0.010 and 0.005 at day 1 and day 2 for the Wong-Baker scale and with p-values 0.020 and 0.017 for VAS scale. Conclusion: Inter-group comparison at baseline, day 1, day 2 showed significant results on day 1 and day 2, suggesting both the products were effective. Intra-group comparison of pain values in both VAS and WONG BAKER scales showed the significance of the mouthwash group, suggesting more efficacy than the tablet. Keywords: Pain, Benzydamine hydrochloride mouthwash, Post-periodontal surgery.