The development of a convenient, safe and scalable process for AZD8329 manufacturing is reported here. Synthesis was achieved in a two-step telescopic process with an excellent overall yield of 75%. In the first step enamine (6) was synthesized with 90% yield through three chemical transformations. In the next step AZD8329 was synthesized from the reactions of 6 and 4-hydrazinobenzoic acid hydrochloride 7 through two chemical transformations. The process is very efficient and economical, and AZD8329 was manufactured in multikilogram scale. A greener approach is demonstrated through usage of a minimum number of solvents and energy and with process mass intensity (PMI) <60 in the manufacturing process.

A simple and practical method of recycling homogeneous catalysts in the Suzuki reaction using appropriate work up conditions is reported here. The commonly used and commercially available homogeneous catalysts 1 (Pd-100) dichlorobis(tri-phenylphosphine)palladium(II), 2 (Pd-106) dichloro[1,1?-bis(diphenylphosphino) ferrocene]palladium(II)-dichloromethane adduct, and 3 (Pd-118) 1,1?-bis(di-tert-butylphosphino)ferrocene] dichloropalladium(II) selected for our study and were recycled successfully for three times using simple acidic and basic work up conditions depending on the presence of amino or carboxylic acid functional group in the product.