A schematic representation of different methods to inhibit SARS-CoV-2 infection.

Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar formed after severe traumatic brain injury as well as spinal cord injury and play a crucial inhibitory role in axonal regeneration by selective contraction of filopodia of the growth cone of sprouting neurites. Healing of central nervous system (CNS) injury requires degradation of the glycosamine glycan backbone of CSPGs in order to reduce the inhibitory effect of the CSPG layer. The key focus of this Viewpoint is to address a few important regenerative approaches useful for overcoming the inhibitory barrier caused by chondroitin sulfate proteoglycans.

Amyloid-β 42(Aβ42), an enzymatically cleaved (1–42 amino acid long) toxic peptide remnant, has long been reported to play the key role in Alzheimer’s disease (AD). Aβ42 also plays the key role in the onset of other AD-related factors including hyperphosphorylation of tau protein that forms intracellular neurofibrillary tangles, imbalances in the function of the neurotransmitter acetylcholine, and even generation of reactive oxygen species (ROS), disrupting the cytoskeleton and homeostasis of the cell. To address these issues, researchers have tried to construct several strategies to target multiple aspects of the disease but failed to produce any clinically successful therapeutic molecules. In this article, we report a new peptoid called RA-1 that was designed and constructed from the hydrophobic stretch of the Aβ42 peptide, 16KLVFFA21. This hydrophobic stretch is primarily responsible for the Aβ42 peptide aggregation. Experimental study showed that the RA-1 peptoid is stable under proteolytic conditions, can stabilize the microtubule, and can inhibit the formation of toxic Aβ42 aggregates by attenuating hydrophobic interactions between Aβ42 monomers. Furthermore, results from various intracellular assays showed that RA-1 inhibits Aβ42 fibril formation caused by the imbalance in AchE activity, reduces the production of cytotoxic reactive oxygen species (ROS), and promotes neurite outgrowth even in the toxic environment. Remarkably, we have also demonstrated that our peptoid has significant ability to improve the cognitive ability and memory impairment in in vivo rats exposed to AlCl3 and d-galactose (d-gal) dementia model. These findings are also validated with histological studies. Overall, our newly developed peptoid emerges as a multimodal potent therapeutic lead molecule against AD.

In May 2022, Bangladesh was ranked fifth in a Global Index comprising of 121 countries’ performance of managing the impacts of COVID-19 pandemic. The Index provided Bangladesh with global recognition of its endeavours that aimed at lowering the number of confirmed COVID-19 cases since the mid-2020, in which the country’s vaccine diplomacy played a greater role. In view of that the present study identified the key elements of Bangladesh’s vaccine diplomacy in the context of the pandemic. The study employed the qualitative approach of the social science research, while the data were generated from both primary and secondary sources. The study found that Bangladesh pursued a proactive vaccine diplomacy with a combination of five key elements: identifying the critical areas of intervention, figuring out the volume of internal demand, counting on multiple sources of vaccines, generating diverse source of external funding and making the most use of ‘soft power’ strategy.