The sections in this article are Introduction Dermoscopy Technical Principle and Development Applications Pigmented Skin Lesions Non‐Pigmented Skin Lesions Conclusion Optical Coherence Tomography ( OCT ) Technical Principle and Development Applications Skin Tumors Inflammatory Skin Diseases Wound Healing Bullous Skin Disorders Other Conclusion Laser Doppler Imaging Technical Principle and Development Applications Skin Tumors Inflammatory Skin Diseases Microcirculation of Chronic Wounds Collagenosis and Rheumatic Diseases Conclusion Confocal Laser Scanning Microscopy ( CLSM ) Technical Principle and Development Applications Topography of Normal Skin Skin Tumors Vascular Skin Lesions Inflammatory Skin Diseases Infections Drug Delivery Conclusion Multiphoton Laser Imaging Technical Principle and Development Applications Topography of Normal Skin Skin Tumors Skin Aging Drug Delivery Conclusion Raman Spectroscopy Technical Principle and Development Applications Molecular Structure of Normal Skin Inflammatory Skin Diseases Conclusion Acknowledgement