Archaeological spatial databases have the potential to enable deep insights into human history. These compilations of data are at the interface of data management and data visualization. Yet issues of data governance such as the nature, management, quality, ownership, security, and accessibility of archaeological spatial databases are under examined in archaeology, a situation that can affect data intensive methods and "big" data approaches. Data governance including laws and policies associated with data have bearing on archaeological practices which, in turn, can impact map visualizations and subsequent decision-making. With the growth of the geospatial web and Web 2.0 technologies, there are increasing opportunities for archaeologists and the general public to collect and engage with digital archaeological data. In Canada, greater numbers of specialists from different sectors (research and education, government, private companies) now accumulate, store, and process digital archaeological data. We draw from the OCAP® (ownership, control, access, possession) principles to shed light on data governance in archaeology, with a focus on archaeological spatial databases in Canadian archaeology. In this context, we draw attention to the rights of Indigenous peoples, the legal and policy issues associated with archaeological spatial databases, and a need for greater engagement with Indigenous data governance principles.

Shark teeth are commonly found in mortuary and ritual contexts throughout the Northeast. On the Maritime Peninsula, shark teeth have been identified in mortuary assemblages spanning the Late Archaic through to the Late Woodland periods (ca. 5000 B.P. to 950 B.P.). Beyond the Maritime Peninsula, shark teeth have been recovered from Woodland period contexts ranging from Chesapeake Bay to the Ohio River. Amerindian perspectivism, or cosmológical deixis, provides a framework for understanding the relationship between humans and animals in hunter-gatherer societies. To explore this relationship, we examine engagements between sharks and humans over a period of 5,000 years, within a socioeconomic perspective. We postulate that shark teeth in mortuary contexts were complex, entangled objects that were both mnemonics and instruments. All at the same time, shark teeth were (1) an emblem of a real creature with spectacular predatory abilities, (2) an icon of transformational and spiritual power, (3) a symbol of a society’s maritime way of life, and (4) a tool–a conduit through which a person could gain access to supernatural abilities. When shark teeth were exchanged, all of these properties may have been transferred, suggesting that reinforcing relationships between societies conducting the exchange was as important as gaining access to the supernatural powers of the teeth.

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We were able to demonstrate, for the first time, a clear exposure-response relationship between fruit fly exposure and specific sensitisation. Facilities housing fruit flies should carefully consider methods to reduce exposure levels in the workplace.

Monoclonal intact immunoglobulin is detectable in the serum of approximately 80% of myeloma patients while SFLC are found to be abnormal in the serum of greater than 90% of patients. One advantage of monitoring SFLC is that they have a half-life of clearance from the serum of 2–6 hours, compared with 20 days for IgG, and can therefore reveal the response to treatment more rapidly. The aim of this study is to determine whether SFLC measurements allow earlier assessment of response to treatment with bortezomib with possible implications to the design and cost of treatment strategy.Patients & Methods Serial serum samples were collected for simultaneous measurement of SFLC and serum paraprotein. Data from 8 patients receiving 2–6 cycles of bortezomib, on compassionate basis, to treat multiply treated myeloma at various stages of relapse are presented. Bortezomib was administered at a dose of 1.3mg/m2 on days 1,4,8 and11. Samples were kept frozen until thawed for SFLC measurement (using Freelite kits; Binding Site, UK on an Olympus Chemistry analyser). Results & Discussion Six of 8 patients showed a response to treatment by EBMT/Blade criteria (>25% fall in paraprotein). In 3 of these patients the tumour SFLC showed a fall and rapid recovery within 10–20 days of a treatment cycle. These patients were monitored over multiple treatment cycles and showed repeated falls in SFLC co-incident with treatment and recovery in between. This appears to correspond with the mechanism of action and biological half life of proteosome inhibition. Recovery of SFLC when seen is rapid (doubling in <10 days). This pattern of tumour response would only be observable with frequent sampling and a tumour marker rapidly cleared from the serum and we believe this is the first reported observation in myeloma patients. In comparison to SFLC, the intact immunoglobulin monoclonal protein did not show the same peaks and troughs. It is likely that the pattern of initial SFLC response is an early indication of tumour response or resistance. Generally the SFLC levels indicated disease response earlier than the immunoglobulin assays. In two of these patients, the response was seen significantly earlier (30 and 70 days). In one remaining patient, serum paraprotein showed disease response whereas SFLC showed no response and subsequently disease progression. Conclusion: We conclude that monitoring SFLC provides a unique opportunity to follow the kinetics of tumour kill, which is obscured by the slow clearance of intact immunoglobulin monoclonal proteins. The pattern of fluctuation in the SFLC levels could suggest a temporary inhibition of tumour protein synthesis rather than tumour kill and re-growth. While extension of this study is ongoing, it does indicate that SFLC can be used as a biomarker to assess response to treatment significantly earlier allowing relevant changes of treatment strategy. This also may have major bearing on cost of treatment and utilisation of resources.