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Purpose We report on the safety and efficacy of eslicarbazepine acetate (ESL) in routine clinical practice. Method Retrospective multicentre audit of outcomes following ESL treatment for localisation-related epilepsy across 7 UK sites (2009)(2010)(2011)(2012)(2013). Results 201 patients with median values for age 43.0 (18-83) years; duration of epilepsy 17.0 (0-65) years; 2 (0-4) concomitant AEDs, 12 months (2 days-53 months) duration of ESL treatment and 0-12 (87.1% ≥2) previous AED exposures. ESL dosage ranged from 400-1600 mg/day. Baseline seizure types comprised secondarily generalised tonic-clonic seizures (78.1%), complex partial seizures (74.1%) and simple partial seizures (23.4%). Psychiatric comorbidity was reported in 29.9% of patients, most commonly mood disorders. 101 patients (50.2%) experienced ≥50% seizure frequency reduction. 39 subjects (19.4%) became seizure free, of whom 11 (28.2%) had 0-1 previous AED exposures. ESL was discontinued in 70 patients (34.8%) for reasons related to tolerability (n=43), efficacy (n=7), both (n=4) or other (n=16). Adverse events (AEs) were fatigue (18.9%), dizziness (10.0%) and disturbance in attention/ concentration (9.0%); most were observed with AED polytherapy. Psychiatric and behavioural AEs (n=6, 3.

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Method A retrospective review of all the neonates who had PICC lines inserted from Jan2016-Jun2018 was collected from online patient data base and case notes. The online Picture Archiving and Communication System (PACS) was utilized to review all the X-rays done post procedure.Variables including gestational age, birth weight, site of line insertion, line tip position on X-ray and its documentation in notes and formal radiology reports, any deliberate readjustment or change in line position in subsequent X-rays, duration of use, associated complications and reasons of removal were reviewed. Detailed review of the babies who suffered complications secondary to PICC line insertion was also done. Results Total 62 PICC lines inserted in 43 babies were reviewed. The median gestational age was 27 weeks while the birth weight was 920 g. Right arm was the most common site of insertion (n=19, 31%). The median age at line insertion was 8d with 43% (n=27) lines passed during the first week of life. Median duration of use of these lines was 5d. Only about 26% (n=17) were optimally placed in the midline veins. Subclavian vein was the most common suboptimal position for the upper limb lines (61%, n=22) while for the lower limb was near the hip joint (n=7, 23%) or the left side of spine with potential risk of involvement of ascending lumber vein(n=5, 22%). About 29% (n=18) of the lines were readjusted, amongst which the line tip within the cardiac silhouette being the most common cause. None of the lines with tips potentially in the ascending lumber vein were readjusted or further investigated. The most common complication leading to early removal was line occlusion (n=8, 13%).Introduction Neonatal hypoglycaemia is a common neonatal problem and there is active debate surrounding screening, associated factors and long term consequences. There is controversy surrounding the outcome of transient neonatal hypoglycaemia but Kaiser et al reported decreased proficiency in literacy and mathematics tests in these infants at follow-up, even when adjusted for gestational age. In 2011, the American Academy of Paediatrics revised the neonatal hypoglycaemia guideline, this outlined the infants at risk for hypoglycaemia i. e large for gestational age, small for gestational age, IUGR, late preterm and maternal gestational diabetes. We have adopted a similar national and local guideline for screening and management of neonatal hypoglycaemia in Ireland. Methods We evaluated the presence of hypoglycaemia <3 mmol/l in our neonatal population over a three month period. We did this using the results from the point of care blood glucose machine. We then performed a retrospective review using the NM-CMS system to view patient records for the neonate and their mother. We were able to determine whether

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