and HL/OL (omniphilic, all liquids wetting), [ 4 ] have a large number of applications including chemical and biological protection, oil-water separation, stain-resistant textiles, "non-stick" coatings, controlling protein and cell adhesion on surfaces, reduction of biofouling, and enhanced heat transport. However, there is no established technique that allows for selectively generating and patterning all four extreme wettabilities [ 5 ] on a single surface, especially at the length scale necessary for microfl uidic control. In this work, we discuss a facile methodology for the fabrication of surfaces with extreme wettabilities by selectively modifying the surface energy and roughness of different paper surfaces.Paper has recently emerged as a promising materials platform for microfl uidic devices due to its low cost, easy disposal, high surface area, capillary-based wetting, fl exibility, and compatibility with a wide range of patterning and printing techniques. [ 6 ] Since the fi rst report of using paper as a base material in microfl uidics by Whitesides et al. in 2007, [ 7 ] a new era of paper-based microfl uidic devices has arisen. [ 8 ] The ability to pattern wetting/non-wetting channels on paper has allowed multiplexed, small-volume fl uid control both in 2D lateral fl ow on a single surface [ 9 ] and 3D fl ow on stacked layers connected through pores. [ 10 ] Generally, fl uidic channels introduced on paper surfaces are composed of wettable domains bounded by non-wettable domains, or by air gaps. [ 11 ] In most cases, paper-based microfl uidic channels have been developed to contain only water or aqueous solutions. [ 12 ] Few reported techniques used for generating patterned wettability on paper result in devices compatible with even a limited number of non-aqueous liquids. [ 13 ] Further, the wettable channels in the paper-based microfl uidic systems reported thus far show no selective wettability with liquids possessing different surface tensions and/or polarities. In other words, all liquids wet these fl uidic channels. Overall, there is no established technique that allows for the selective generation of all four "extreme wettabilities" [ 5 ] on paper-based microfl uidic channels; that is, the four possible combinations of wetting of oil (oleophilic -OL or oleophobic-OP) and water (hydrophilic-HL and hydrophobic-HP) on a surface. The four extreme wettabilities are: HP/OP (omniphobic, all liquids non-wetting), [ 1 ] HP/OL (water nonwetting, oil wetting), [ 2 ] HL/OP (water wetting, oil