Germs are present in all areas of everyday life and can lead to dangerous infections. Surfaces with antimicrobial properties are used to reduce the risk of infection in sanitary facilities and hospitals. Apart from the addition of biocides or antibiotic agents to synthetic materials, research shows that it is possible to use the semiconductor titanium dioxide (TiO2) to generate antibacterial surfaces. Photocatalytically active TiO2 leads to the development of reactive oxygen species (ROS) that are able to kill germs. The aim of this research is to use TiO2 to generate antibacterial bulk material. Nanostructured TiO2 particles were incorporated into silicone rubber to obtain a photocatalytic active polymer surface. High temperature vulcanizing (HTV) silicone rubber was used as a matrix material, and samples with 10 wt% of TiO2 were produced. The distribution of TiO2 particles in the matrix was analyzed via light microscopy. The photocatalytic activity on the surface of the test samples was studied via microbial testing with E.coli bacteria. The samples showed different intensities of the photocatalytic effect depending on the type of additive. The effort to create a germ reducing silicone rubber surface by using TiO2 as an additive was successful.