Background. Because of the growing incidence of obesity, the use of synthetic antiobesity medicines as weight-loss agents has grown in popularity, although their usefulness has yet to be established. Two of such medicines are Aplex and Venera. This study is designed to determine the potential dangers of Aplex and Venera on certain biochemical and physiological indicators in obese adult male rats. Methods. Twenty-one obese male albino rats (9 weeks old and having a body mass of 220 ± 20 g) were divided into three equal groups: the control group (vehicle treatment), the Aplex group (0.1 mg/kg/day) for 30 days, and the Venera group (0.1 mg/kg/day) for 30 days. Results. The values of serum glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), total protein, total cholesterol (TC), high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), TC/HDL ratio, testosterone, thyroxine (T4), and leptin did not differ significantly between the treated and control groups. In contrast, the treated groups had substantial changes in bodyweight, serum alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), albumin, globulin, albumin/globulin ratio (A/G ratio), triglycerides (TG), low-density lipoproteins (LDL), LDL/HDL ratio, urea, creatinine, and triiodothyronine (T3) levels. Conclusion. The findings indicate that Aplex and Venera have negative impacts on crucial biochemical and physiological indicators, particularly liver and kidney functioning.

Obesity poses a significant health danger. The effects of green coffee extract (GCE) and turbo slim blue (TSB) on decreasing the body weight (BW) and their impact on various physiological indicators of metabolic state in obese rats were investigated in this study. Twenty-one male rats weighing 320-360 g were distributed into three groups. Rats were treated with the following for 4 weeks: distilled water (control), GCE (10 mg/kg), and TSB (10 mg kg). All measurements are percent (%) BW changes, pancreatic function markers (insulin, glucose, HOMA-IR), protein, and lipid indicators. Thyroid hormones, leptin, testosterone, liver, and renal function markers were also measured. Relative to the control group, GCE-treated rats significantly reduced the % of the change in BW, glucose, HOMA-IR, and leptin. GCE significantly increases T3 and T4. In addition, GCE-treated rats showed decreased serum lipids and increased serum testosterone levels. Biomarkers of protein metabolism, liver, and kidney function were unaffected by GCE. In contrast to GCE, the loss of BW induced by TSB is associated with a significant rise in liver and kidney function, which is a marker of toxicity. Therefore, GCE can be considered as a harmless and effective additional therapy to reduce BW.