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The PTB-suction prosthesis has been studied by a roentgenological technique. There is complete contact between the skin of the stump and the plastic inner surface of the socket. The movement of the stump in the socket is minimal. The displacement of the skeletal stump is reduced to half in the PTB-suction prosthesis, compared with the strap-suspended PTB prosthesis. As a result, the stability between stump and socket is increased, provided that the stump is sufficiently long. Skin sores are avoided. The prosthesis, when adequately fitted, guarantees a good circulation within the stump and a cosmetically favourable fit with a feeling of walking with "a normal leg".

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SUMMARY The effect of vagotomy on gallbladder function was investigated in a clinical and experimental study. In the clinical study both the size of the gallbladder and its capacity to respond to cholecystokinin were evaluated radiologically before and after vagotomy. In studies in the rabbit, both the immediate effect of vagotomy on the gallbladder and the effect of varying doses of cholecystokinin on gallbladder pressure were studied before and after vagotomy. In studies in the cat the long-term effect of vagotomy was studied with respect to the histology of the gallbladder and the composition of bile.The clinical investigation showed that vagotomy was followed by a significant increase in the volume of the gallbladder and that the effect of the cholecystokinin on the gallbladder remained unchanged after vagotomy. In experiments in the rabbit it was found that cholecystokinin in a dose of 1 unit/kg body weight exerted a somewhat lesser effect on gallbladder pressure after vagotomy than before, while after vagotomy a dose, approximately four times greater, resulted in a stronger gallbladder response. Further, the experiments showed that the chemical composition of the bile seemed to be altered after vagotomy, while the gallbladder remained histologically essentially unchanged.

This study is a detailed analysis of data obtained from 127 experiments on 90 paralysed and ventilated cats regarding the CNS toxicity of nine local anaesthetic agents as evidenced by seizure activity on the EEG. It is shown that an increase in Pco2 or aH+ caused increased CNS toxicity, i.e., smaller i.v. doses were required to elicit seizure activity, and that the underlying metabolic acid‐base state can considerably modify this, a metabolic alkalosis decreasing toxicity, and vice‐versa. The probable mechanisms of this process involving relationships between pH and the local anaesthetic cation/base ratios in plasma and neural tissue are discussed. It is finally recommended that local anaesthetic convulsions be treated by adequate artificial ventilation, which by lowering the Pco2 in the brain will diminish the local anaesthetic toxicity and thus treat the root cause.ZUSAMMENFASSUNGDiese Untersuchung stellt die Detailanalyse von Ergebnissen dar, die bei 127 Experimental an 90 paralysierten und künstlich beatmeten Katzen gewonnen wurden in Hinblick auf die ZNS‐Toxizität von neun Lokalanaesthetika, dargestellt mittels Krampfaktivität im EEC Es zeigte sich, daß eine Erhöhung des PCo2 oder der Wasserstoffionenaktivität (aH+) die ZNS‐Toxizität erhöhte, d.h. es waren geringere i.v. Dosen erforderlich, urn Krampfpotentiale auszulösen. Es zeigte sich ferner, daß der zugrundeliegende metabolische Säure‐Basen‐Status dies beträchtlich modifizieren kann, wobei metabolische Alkalose die Toxizität reduziert und umgekehrt. Der wahrscheinliche Mechanismus, an dem wohl Beziehungen zwischen pH und der Lokalanaesthetika‐Kationen‐Basen‐Relationen im Plasma und im Nervengewebe beteiligt sind, wird diskutiert. Schließlich wird empfohlen, durch Lokalanesthetika bedingte Krämpfe mit adäquater künstlicher Beatmung zu behandeln, damit der Senkung des Pco2 im Gehirn die Toxizität des Lokalanaesthetikums vermindert und mithin das Übel an der Wurzel gepackt wird.