The chronic kidney disease (CKD) is often accompanied to the chronic pulmonary disease (COPD) III stage and metabolic syndrome, (MS) which is because to the persistence of arterial hypertension and disturbances in hydrocarbon metabolism. Materials and methods. There were examined the 52 patients with III stage COPD, combined with MS, aged 51,3±4,2 years old, among them 23 with COPD, combined with MS and CKD I-IIstage (the main group). The compared group was included the 29 patients with COPD, combined with MS, without signs CKD. The all persons were examined by immunology investigation with the detection of cell and humoral immunity indexes and cytokine level. Results and discussion. The breath function data’s, the arterial hypertention stage and level did not have the significant differences. All the patients had the creatinine clearance not less than 60 ml/min/1,73m2. The detection of immune status shows the decrease of T-cell amount, especially the T-cytotoxical lymphocytes/ supressors, the significantly increase level ofactivated Tcells with early activated markers, those, which expressed adhesion molecule ICAM-1 and FAS- receptor, autoimmune and inflammatory changes in blood serum. Conclusions. The available ofСKD in patients COPD, combined with MS, initiated the more high activity of system immune inflammation in atherosclerosis manifestation as the morphological substrate of MS.

The aim: The aim of the work was to determine the leading epidemiological, diagnostical features, disturbance of spirometric indices, changes in the immune system in servicemen with COPD, who take part in Joint Forces Operation (JFO). Materials and methods: 89 male patients were examined, who sought medical help for COPD, group B. They were divided into two groups. 1 group (42 patients) − with COPD, who took part in the JFO not more than 6 month, the 2 group consisted of 47 patients with COPD, who took part in the JFO during the period more than 6 month. Results: The patients in the group 2 had veraciously more points of cough and sputum expectoration in daily amount of 30 and more ml. The type of sputum in 53.2% patients was predominantly mucus-pus. There were also more percentage of patients with feeling short of breath and the high point, achieved at CAT. There were significant differences in systolic and diastolic blood pressure levels, LV mass index between two groups. Conclusions: It was found that servicemen who took part in JFO for more than 6 months had a more severe course of COPD with a higher score in the CAT and probably lower obstructive ventilatory indices, in a probably higher percentage of cases there were detected such a concomitant pathology as AH stage II and GERD. They had Th17 immune response predomination with significant elevation of IL-17, TGF-β, IL-6 concentrations in serum and high concentration of soluble adhesion molecules. KEY WORDS: Obstructive ventilatory defects, immune, external respiration function, fuel combustion products

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