Therapy of liver failure is a common and insufficiently resolved problem. One of the options for its solution it is a liver transplantation. However, this method has a number of drawbacks, which include a limited number of donors and transplant rejection. The use of autologous hepatocytes would allow significant progress to solve the problem under discussion. The work considers a method that allowed obtaining autologous hepatocytes by transdifferentiation of multipotent mesenchymal stromal cells using genetic engineering methods.

Damage to the cartilage surface of the joints is a common pathology. Conventional drug therapies are effective only at the initial stage of the disease and only slow down the further development of the disease. In subsequent stages, it is necessary to apply surgical methods from replacing a defect to complete prosthetics of a damaged joint. In order to replace defects in cartilage tissue, a three-dimensional bioequivalent was created based on autologous multipotent mesenchymal stromal cells.