Previously, long-term changes in the motor cortex have been reported after repetitive electrical nerve stimulation (rES) as well as after motor exercise. The purpose of this study was to investigate whether the effects of voluntary motor cortical drive and of rES on the motor cortical output in healthy subjects interact with each other. A 30-min exercise session was performed during the following conditions: rES of the right common peroneal nerve (CPN) during rES at rest (A); voluntary exercise of the right ankle dorsiflexors alone (B); rES combined with voluntary dorsiflexion exercise (C); voluntary exercise of ankle plantar flexors alone (D); and plantar flexion exercise combined with rES (E). Motor evoked potentials (MEPs) were obtained before and after the exercise with a stimulation intensity of 125% of the threshold of the relaxed right tibialis anterior (TA). rES was ON for 1 s and OFF for 2 s in a cycle, and consisted of trains of five pulses, duration 1 ms and frequency 30 Hz, as applied in functional electrical stimulation (FES). MEPs of the TA muscle elicited after the training were increased in A by 38%, in B by 35%, and in C by 66%. In D and E, the MEPs of TA were decreased by 29% and 35%, respectively. The effect was maintained for at least 30 min after the nerve stimulation was completed. Consistent with previous studies (Khaslavskaia et al. (2002) Exp Brain Res 145:309-315), MEPs after the CPN rES are shown to be partly due to increased TA cortical excitability. These results suggest that the effect of FES on motor cortical excitability depends on the concurrent motor cortical drive present at the time of FES, and the combination of these factors modulates neural excitability and probably reorganization. The decrease in motor cortical excitability after plantar flexor exercise probably means that voluntary effort antagonistic to the electrical exercise is stronger and cancels out the effects of rES. Improving FES effects through an agonist voluntary drive implies an enhancement of sensorimotor reorganization through the addition of a voluntary component to a trained movement. Possible mechanisms and implications of these results on the rehabilitation of patients with paralysis and spasticity are discussed.

The purpose of this study was to investigate whether repetitive electrical stimulation of the common peroneal nerve (CPN) is associated with changes in the motor response of the tibialis anterior (TA) muscle elicited by focal magnetic stimulation of the motor cortex. Motor evoked potentials (MEP) with a stimulation intensity of 125% of the threshold of the relaxed right TA were obtained before, during, and after repetitive electrical stimulation of the CPN (trains of five pulses of 1 ms, at a frequency of 200 Hz, repeated every second with a 30-min duration). The MEP of the TA muscle elicited after repetitive electrical stimulation were increased by 104% (range: 18-263%), and the increase was maintained for up to 110 min (range: 15-110 min) after the end of nerve stimulation. This increase in the MEP of the TA muscle was associated with a decrease in the threshold from the stimulation-response curve. Furthermore, during that period the early component of the TA stretch reflex as well as the latency of the MEP did not significantly change. To further test the origin of the increased MEP, complementary experiments showed that MEP elicited by transcranial electrical stimulation (TES) were also increased, but to a lesser degree (approximately 50%) than MEP elicited by TMS. It can be concluded that short-term nerve repetitive electrical stimulation of the lower extremities in healthy human participants can lead to a long-term increase in the contralateral MEP. As TES is believed to mainly activate the axon and not the soma of the cortical cells, the increased MEP cannot be explained exclusively by changes in the motor cortex cell excitability, but also by changes in subcortical neural structures involved in the excitation of spinal motoneurons. The results of this study allow the speculation that it would be possible to use repetitive electrical stimulation in the rehabilitation of patients with lower limb muscle weakness and spasticity.

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The aim of this study was to investigate the influence of short-term repetitive electrical stimulation (rES training session) on the motor-evoked hemodynamic responses. The fMRI echo-planar images (EPI) were recorded before and after the rES training. The right median nerve (MN) was stimulated during rES. The rES training resulted in a significant increase in activity in a number of supraspinal regions, including sensorimotor and associative cortical areas. On the subcortical level, the effect was also found in the cerebellum, the midbrain, and the thalamus. Possible mechanisms of the neuronal plastic changes observed after rES, and memory processes involved in learning are discussed.