Background:The nutrient foramen (NF) is the largest of the foramen present on the shaft of long bone allowing nutrient artery to enter the bone. These arteries are important during active growth period of embryo and fetus and during the early phases of ossification. They provide 70-80% of the interosseous blood to long bones. The context and purpose of the study:The study was conducted on 156 long bones of lower limb available in the department of anatomy, Government medical college, Aurangabad.The aim of the study was to note the morphology and variations of nutrient foramen in human adult lower limb long bones and to discuss its clinical importance. We observed only diaphyseal nutrient foramens of these bones for size and number. Size of foramens were measured using hypodermic needle and foramen were classified as secondary (SF) or dominant (DF). Number of foramens or their absence was noted. Distance of nutrient foramen (DNF) was measured using Vernier caliper from highest point of head of femur and fibula to foramen and from center of tibial condyles on posterior aspect of tibia. Total length of bone (TL) was measured using standard osteometric board. The location of all nutrient foramen in upper, middle or lower third of bone was determined by calculating a foraminal index using Hughes formula. Results:We observed that maximum tibia had single foramen followed by fibula and femur. We found maximum five foramens on two left femurs. One femur had secondary foramen on anterior surface. Nutrient foramens were totally absent in six fibulas. According to foraminal index, tibia had maximum nutrient foramen in upper third of shaft while femur and fibula had them on lower third. Potential implications:On radiograph, nutrient foramen mimics longitudinal stress fracture or may be misdiagnosed as lytic bone lesions like osteoid osteoma. Precise knowledge of nutrient foramen and its variations is necessary for doctors to predict prognosis of grafts, tumors, fractures of bones and also useful for anthropologist during interpretation of height from a fragment of bone. Conclusions:The maximally observed position of nutrient foramen is in middle third of the shaft of femur and fibula while upper third of shaft in tibia. Knowledge of which is important clinically for proper diagnosis and planning of surgery and also to predict the prognosis.