Nasal administration offers an interesting promising alternative technique to the parenteral route for achieving systemic drug effects. Now a day many drugs have better systemic bioavailability through nasal route as compared to oral administration. Microemulsion is dispersed, macroscopically homogenous thermodynamically stable, optically transparent, single phase system, formed by spontaneous solubilisation of two immiscible liquid, in the presence of surfactants. Microemulsion offers number of advantages than drug formulation for nasal drug delivery. Ziprasidone is lipophilic, benz-isothiazoyl-piperazine derivative, used in the treatment of schizophrenia, mania and mixed states associated with bipolar disorder. The microemulsion was prepared by precipitation method. The characterization of microemulsion formulation includes determination of viscosity, pH, drug content, refractive, conductivity measurement, zeta potential analysis and particle size analysis. In-vitro drug permeation studies were done by using Keshary Diffusion cell. All ME formulations were shown fast drug permeation 99.50 % for ME 2 within 1 h and 99.40 % for ME 6 within 100 minutes since the ME 2 which is optimized on the basis of in-vitro study. Nasal mucoadhesive drug delivery system is designed with an aim to target the drug and to maintain the dosage form at its absorption site for a rapid onset of time. This will result in the enhancement of the absorption of the drug, which will in turn reduce the presystemic metabolism; increase the bioavailability of the drug, initiate rapid onset of action and thus will decrease the dosing frequency and dose related side effects of the drug. For this purpose in microemulsion system is preferred over conventional solution system

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Chlorella vulgaris extract was purchased from the authenticated source and identified by using different phytochemical test. AnimalWistar rats were used for current study. Animal were placed in polyethylene cages with free access of feed and water at standard temperature 22°C and relative humidity 65%. The animals were maintained according to guidelines given by Committee for the Purpose of Control and Supervision of the Experiments on Animals (CPCSEA). The experimental protocols were approved by the IAEC. Drug and ChemicalsCarrageenan (Sigma Aldrich), ibuprofen (purchased from local pharmacy store), Cytokine kits was purchased from Elab science, Egg albumin, Indomethacin (purchased from local pharmacy vender).