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Rotheca serrata (Lamiaceae), a highly medicinal plant is used as an antidote for snakebite and the plant possesses medicinal properties like hepatoprotective, antitussive, antioxidant, anticancer, neuro-protective, used in rheumatoid arthritis and is also a α-glucoside inhibitor. This work aimed to study the anticancerous effect of Rotheca serrata (root and leaf) on cancer cell lines MCF-7 (breast cancer cell line) and Neuroblastoma SH-SY5Y. The results indicated that the Methanolic extract of Rotheca serrata (root and leaf) showed high anticancer activity. Different concentrations of plant extracts (25, 50, 100, 200, 400 μg/ml) were used to study the anticancerous activity, amongst which the significant results were obtained for 400 μg/ml concentration (both root & leaf). Effective anticancer activity against MCF-7 breast cancer cells was shown in methanolic extracts and were expressed as IC 50 values, in root (IC 50 value= 61.8259 ± 7.428 μg/ml) and in leaf (IC 50 value equals to 78.1497 ± 6.316 μg/ml). The MTT assay in case of neuroblastoma (SH-SY5Y) cell lines revealed that 400 μg/ml concentration of leaf methanolic extract showed effective inhibition of cancer cells with IC 50 value 37.8462 ± 2.957 μg/ml as compared to IC 50 value of root methanolic extract which was 57.0895 ± 2.351 μg/ml.

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Homoeopathic cure is based on law of similars. The process of competitive enzyme inhibition through which diseases are treated in Modern medicine also applies the principle of similars. But the explanation of how the homoeopathic cure takes place is philosophical, whereas that of competitive inhibition is scientific. By drawing a parallel between these two processes, the purpose is to formulate a proposition whether the homoeopathic cure could possibly be due to the competitive inhibition between the disease and medicinal forces. It also shows that the application of law of similars is not limited to Homoeopathy and dynamic plane.