No abstract

Furosemide–Na–trihydrate displayed aqueous solubility of about 4000 fold higher than that of furosemide while furosemide–K–monohydrate has over 10 000 times improved solubility.

Only one X-ray crystal structure of the parent quinolone antibiotic nalidixic acid is known in the published and patent literature. A systematic search for new solid-state forms of the drug yielded two polymorphs (forms II and III) and six cocrystals with resorcinol, catechol, hydroquinone, pyrogallol, orcinol, and phloroglucinol. Of these, X-ray crystal structures were determined for polymorph II and cocrystals with resorcinol, catechol, hydroquinone, and pyrogallol, whereas the remaining solid forms were identified by their unique powder X-ray diffraction patterns. Nalidixic acid is intramolecularly O−H···O hydrogen bonded in a six-member ring, and its molecular dimers are assembled via C−H···O synthon. The OH donors on phenolic coformers H bond with the α-keto acid moiety of the drug as connectors and spacers. Intermolecular drug−drug C−H···O interactions in polymorphs are replaced by strong drug−coformer O−H···O hydrogen bonds in cocrystals.