Corona virus disease-2019 (COVID-19) caused by severe acute respiratory syndrome corona virus-2 (SARS CoV-2), a highly contagious single stranded RNA virus genetically related to SARS CoV. The lungs are the main organs affected leading to pneumonia and respiratory failure in severe cases that may need mechanical ventilation. Occasionally patient may present with gastro-intestinal, cardiac and neurologic symptoms with or without lung involvement. Pathologically, the lungs show either mild congestion and alveolar exudation or acute respiratory distress syndrome (ARDS) with hyaline membrane or histopathology of acute fibrinous organizing pneumonia (AFOP) that parallels disease severity. Other organs like liver and kidneys may be involved secondarily. Currently the treatment is principally symptomatic and prevention by proper use of personal protective equipment and other measures is crucial to limit the spread. In the midst of pandemic there is paucity of literature on pathological features including pathogenesis, hence in this review we provide the current pathology centered understanding of COVID-19. Furthermore, the pathogenetic pathway is pivotal in the development of therapeutic targets.

BACKGROUND We wanted to evaluate the role of platelet indices in differentiating reactive and clonal thrombocytosis. METHODS This is a cross sectional observational study conducted for two years among 150 patients with platelet counts of 5 lac and above. Thrombocytosis and utility of platelet indices like Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) for the differential diagnosis of thrombocytosis were done. RESULTS Out of total 150 cases, 144 (96 %) had reactive thrombocytosis, and 6 (4 %) had clonal thrombocytosis. Infectious aetiology is seen in 64 (42.6 %), tissue injury 35 (23 %), rebound thrombocytosis 22 (14.6 %), anaemia 13 (8.6 %), multiple causes 8 (5.3 %), clonal aetiology 6 (4 %), and inflammatory 2 (1.3 %). Patients with reactive thrombocytosis showed a lower mean platelet volume and platelet distribution width compared to primary thrombocytosis. In reactive thrombocytosis MPV range, 6.0 - 8.0 fl with mean MPV 6.5 fl and PDW ranges from 14.0 - 16.2 % with mean PDW 15.3 %. In clonal thrombocytosis MPV range, 6.9 - 8.5 fl with mean MPV 7.9 fl and PDW range was 15.9 - 17.2 % with mean PDW 16.4 %. CONCLUSIONS On analysing the platelet counts and indices, patients with high counts, low MPV and PDW suggested reactive aetiology and patients with high counts and high MPV and PDW suggested clonal aetiology. KEYWORDS Thrombocytosis, Mean Platelet Volume, Platelet Distribution Width

BACKGROUND The World Health Organization (WHO) has declared Coronavirus disease 2019 (COVID - 19) as a global public health pandemic. Clinical and laboratory biomarkers to predict the severity of corona virus 2019 are essential in this pandemic. Lymphocyte count has been a marker of interest in order to investigate the association of lymphocyte count and severity of COVID-19. We would like to analyse the relationship between absolute lymphocyte count (ALC) & COVID-19 disease severity. METHODS We performed a retrospective study on patients admitted to Government general hospital, Suryapet for COVID-19 illness from September 1st 2020 to September 16th 2020. Age, gender and complete blood count of patients admitted in the hospital was collected. Haemoglobin, total leucocyte count (TLC), absolute neutrophilic count (ANC), absolute lymphocyte count (ALC) and platelet counts were compared between ICU and Non-ICU groups and comparison of absolute lymphocyte counts in each group - ICU alive, ICU death and non-ICU groups was carried out. RESULTS 134 patients who were admitted in the hospital were analysed. Mean age and gender were compared between ICU and Non-ICU groups. We compared ALC between ICU alive, ICU death and non-ICU groups. Mean ALC in ICU death group was 0.81, in ICU alive group 1.04 and in non-ICU as 1.75. We found that patients with disease severity have lower absolute lymphocyte counts. In addition to this we also found that there was neutrophilia and lower haemoglobin levels in ICU patients. CONCLUSIONS We conclude that lymphopenia, defined as absolute lymphocyte count less than 1.1 x 109 /L may be useful in predicting the severity of COVID-19 illness. KEYWORDS COVID-19, Absolute Lymphocyte Count (ALC), Lymphopenia, SARS COV2

To evaluate the Cytomorphological patterns in cervical lymph nodes by using fine needle aspiration cytology, and analyze the usefulness of the fancy procedure. Materials and methods: In this study total 100 patients with cervical lymph node swelling were included in the study, who had presented to the department of pathology in our tertiary care center. Results: Out of 100 clerical lymphadenopathy cases majority were Tuberculous lymphadenitis 32 (32%), Reactive lymph adenitis 30(30%), Granulomatous lymphadenitis 22(22%), Nonspecific lymph adenitis 7(7%), Necrotizing Lymph adenitis (5%), Metastatic Deposits 2(2%), Lymphoma 2(2%). Conclusion: FNAC is a cheap, reliable, easy procedure for the early detection of disease pathology in lymph nodes.

Background: To evaluate the prognostic value of Neutrophil to lymphocyte ratio (NLR) in Covid -19 patients at our district area hospital/ Teritary care center. Methods: It is a prospective study from 1-8-2021 to 30-9-2021. Patients  who presented with complaints of  Fever, sore throat, body pains, cough, breathlessness, diarrhoea were evaluated at the triage area of the Hospital. Throat swab was taken and RT-PCR was done and only 200 confirmed cases were included in the study. Patient blood samples were collected and processed in SYSMAX 5 -part, Heamotology analyser in the Hospital Central Laboratory. The patients CBP was processed in the laboratory NLR value calculated and tabulated. Results:  Out of 200 cases number of Males were 145(72.5%) more compared to the female were 55(27.5%), with NLR value 1.0-3.9 in74 cases(37%) ,4.0- 6.9 in 63 cases (33%) , 7.0 – 9.9 in 25 cases (12.5%), 10-12.9 in 17 (8.5%) cases , 13-15.9 7 cases(3.5%), 16 -18.9 3 cases(1.5%) ,19-21.9 9 cases(4.5%) ,22-24.9 0 cases, 25-27.9 0 cases , 28-30.9 2 cases ( 1%). Conclusion: NLR Value more than 3.5 found to be significant and it is correlating with the patients symptoms.