The purpose of this study was to determine the effect of applying hybrid learning through Quipper media on improving mastery of 2013 curriculum specialization material in inclusive schools. The research method used was a quasiexperimental research design with a control group design pretest random pretest. The study sample was a class X student in one of the senior high school inclusive in the city of Bogor with a random sampling technique. From the results of the study, it can be concluded that Quipper's media improved the mastery of students' concepts better than Edmodo's media in inclusive schools.