Aim: Denture base materials were subjected to cigarette smoke for the purpose of determining their surface roughness. Materials and Methods: Polymethylmethacrylate and flexible denture base materials were used to manufacture 40 specimens for this study (20 for each). Each sample was randomly assigned to one of four groups: control, flexible, and heat-cured denture base material samples. The heat-cured denture material samples were the only ones that had been exposed to cigarette smoke (subgroup III). There was a control group for each group. For the smoke test groups, distilled water was utilised, whereas cigarette smoking was used for the water test groups. Each participant in the trial was exposed to six cigarettes in a specially created smoking area. Surface roughness differences between pre- and post-smoking samples were analysed using a profilometer. The data was analysed using a paired comparison and an independent comparison. Groupings differed significantly in their initial roughness and final roughness, according to results from a paired t-test. Conclusion: Surface harshness of tobacco-smoke-exposed specimens of both the intensity-restored and the adaptive dental replacement base materials was greater.