Objective: To evaluate the prevalence and clinic-etiologic profile of thrombocytopenia in pregnancy: Materials and Methods: The present hospital based observational study was conducted in the Department of Obstetrics and Gynecology, Patna Medical College and Hospital, Patna, Bihar from July 2016 to January  2017. A detailed obstetrics history was obtained and maternal high risk factors like preeclampsia, eclampsia, DIC, HELLP syndromes etc were noted. Medical history like anemia, malaria, dengue, liver disorder, current or previous bleeding problems, family history of bleeding & transfusion history were noted. Clinical findings suggestive of thrombocytopenia like petechiae, ecchymoses etc. were noted. Results: Out of total 74 patients, Gestational thrombocytopenia was the most common etiological factor with 41.9% cases followed by 35.1% for hypertensive disorders including HELLP syndrome followed by 6.8% for Malaria and dengue. The most common hemorrhagic presentation was petechiae, ecchymosis & purpura in 33.8% cases. Among the thrombocytopenic pregnant women in our study, 60.8% had mild thrombocytopenia, 24.3% had moderate thrombocytopenia and 14.9% had severe thrombocytopenia Conclusion: The study demonstrated that thrombocytopenia is a frequent finding in pregnancy. It has many potential causes but gestational thrombocytopenia (GT) predominates. Degree of thrombocytopenia was mild to moderate. Keywords: Pregnancy, Thrombocytopenia, Petechiae, Ecchymosis

Introduction: Uterine leiomyoma is the commonest benign gynaecological tumour occurring in upto20% to 80% of women reaching perimenopausal stage and 40% has symptoms severe enough to warrant therapy. Recent evidence suggests that progesterone is essential for maintenance and growth of uterine leiomyoma and that estrogen is required only for upregulation of progesterone receptors. Mifepristone is synthetic steroid, derived from norethindrone, progesterone receptor modulator with primarily antagonistic property. The present study aimed to evaluate the efficacy and safety of low dose of mifepristone in medical management of uterine leiomyoma Materials and methods: the study is being conducted in obstetrics and gynecology department of PMCH. In 2 years, 100 patients with age between 40-50 years with multiple or single fibroid with symptoms requiring treatment with normal blood biochemistry profile were studied. Two groups were made, each of 50 patients. Group I was given mifepristone in dose of 25mg/day; and Group II was given mifepristone in dose of 10mg/day for 3 months. Patients were followed up at 3 months and 6 months of starting treatment. Results: In both groups, there was decrease in size of fibroid, control of bleeding, improvement of symptoms and hemoglobin profile. Conclusion: Low dose of mifepristone is useful for decreasing the size of fibroid, control of bleeding, improvement of hemoglobin profile and for medical management of fibroid. Keywords: mifepristone, fibroid, management

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Aim: To evaluate the relationship between of thyroid dysfunction and abnormal Uterine bleeding. Materials and Methods: The present retrospective hospital based study was conducted in the Department of Obstetrics and Gynecology, Patna Medical College and Hospital, Patna, Bihar from September 2016 to July 2017.110 patients with abnormal uterine bleeding of were found to be eligible for inclusion in the study. Results: Mean age of the study subjects was 32.71 years. Majority of patients was multiparous (58.2%). 40.0% of women presented with complaint of heavy menstrual bleeding. 42.7% of the study subjects were having thyroid dysfunction Conclusion: Abnormal uterine bleeding found strongly associated with thyroid related disorders. Hence the evaluation of thyroid function forms an essential component among abnormal uterine bleeding patients Keywords: Abnormal Uterine Bleeding, Thyroid Dysfunction

Aim: To evaluate degree of chronic pelvic pain and degree of adhesion. Materials and Methods: The present clinico-observational study was conducted in the Department of Obstetrics and Gynecology, Patna Medical College and Hospital, Patna, from December 2016 to December 2017.among 40 women diagnosed with endometriosis. Pain intensity was assessed by visual analogue scale (VAS) and categorized as mild, moderate or severe accordingly. This was followed by laparoscopy/ laparotomy and staging of endometriosis which was done as per the American Society for Reproductive Medicine (ASRM) classification system. Corrective procedures were done simultaneously. Results: Mean age of study cohort was 30 ±5.75 years. As per VAS, majority felt moderate pain (47.5%) in present study. The presenting symptoms were dysmenorrhoea (45.0%), dyspareunia (17.5%) and chronic pelvic pain (35.5%). Conclusion: Degree of tubal involvement was more in all the women as compared to ovarian involvement. Post-operatively the intensity of the pain subsides. Keywords:  VAS, Adhesion, Endometriosis, Tubal, Ovarian