Introduction: Given the limitation of non-specific nature of signs, symptoms and physical examination in diagnosing sepsis; especially in young children, a diagnostic marker that will aid in an early diagnosis is needed. Procalcitonin satisfies most of the criteria for smart biomarker of sepsis. The present study is done to compare procalcitonin (PCT) with C-reactive protein (CRP) as a diagnostic marker of sepsis in children. Materials & Methods: A prospective observational study was done in the Department of Paediatrics, ASRAM Medical College and Hospital, Eluru from July 2015 to June 2016. Children admitted to PICU during the above tenure are included in the study. Specific inclusion and exclusion criteria are formulated with a sample size of 100. Procalcitonin level is analyzed by enzyme linked immunoluminometric assay using Elecsys Brahms PCT kit.CRP analysis is done using immunoturbidometry which is a quantitative method. Results: Out of 100 children 72 have sepsis. The mean procalcitonin level in children with sepsis is 19.09 ± 24.53 ng/ml compared to 0.34 ± 0.49 ng/ml in children without sepsis. In comparing sepsis with asepsis, PCT (Cutoff value of 0.58ng/ml) have a better sensitivity (90.3%) and specificity (92.9%) than CRP (Cut off value of 0.7mg/dl) sensitivity of 87.5% and specificity of 57.1%. Conclusion: PCT offers better sensitivity and specificity than CRP, to differentiate sepsis from asepsis. In febrile children PCT is a better diagnostic marker of sepsis than CRP.

A theoretical analysis of an asymmetric roller bearing system with cavitation that is hydro-dynamically lightly loaded and lubricated by a thin, incompressible fluid is presented. The lubricant adheres to the non-Newtonian Bingham plastic fluid concept, in which the viscosity of the fluid should change depending on the mean film temperature. The continuity and momentum equations, which regulate fluid flow, are first solved analytically and then numerically using MATLAB. Through graphs and tables, some key bearing features are addressed and further explained. This leads to the conclusion that there is a discernible difference between Newtonian and non-Newtonian fluids in terms of pressure, temperature, load, and traction. The findings are good in line with the body of literature.

Background: Necrotizing enterocolitis (NEC) is mostly limited to preterm babies due to immaturity of gut. NEC is one of important cause of neonatal mortality and morbidity in the neonatal intensive care units all over the world.Aim of study is to find the antenatal and post-natal risk factors associated with necrotizing enterocolitis in neonates admitted to NICU.Methods: A prospective study was conducted on 45 neonates with necrotizing enterocolitis fulfilling the predetermined inclusion criteria. A detailed antenatal history including all maternal risk factors, birth history including the need for resuscitation and type of resuscitation was recorded. The gestational assessment was done by the New Ballard Score.Results: Pregnancy induced hypertension accounts as a risk factor to most of the cases of NEC 18 (40%), followed by setting for sepsis 12 (26.6%), least being gestational diabetes mellitus 1 (2.2%).Conclusions: Prematurity is found to be the most common risk factor followed by patent ductus arteriosus and sepsis. Most common antenatal risk factor was PIH (Pregnancy induced hypertension).